An introduction to the Global Parkinson’s Genetics Program (GP2)
Objective: Expanding the current understanding of the genetic architecture of Parkinson’s disease (PD), accelerate discovery and validation of novel disease-causing genetic mutations and provide training…Apolipoprotein E ε4 and risk of freezing of gait in early Parkinson’s disease
Objective: To investigate the association between Apolipoprotein E (APOE) genotype and freezing of gait (FOG) in Parkinson’s disease (PD). Background: This cohort study using the…A novel likely pathogenic SNCA variant associated with Parkinson’s disease
Objective: To report a novel SNCA likely pathogenic variant. Background: The A53T mutation in the SNCA gene, encoding alpha-synuclein (a-syn), was the first established genetic…mRNA level and variants of the SCARB2 gene in the pathogenesis of Parkinson’s disease
Objective: The aim was to test an association of rs6812193 and rs8475 of the SCARB2 gene with Parkinson’s disease (PD) in case–control study in Russia.…Glucocerebrosidase Deficiency Mediates Propagation of Protein Aggregation via Extracellular Vesicle Dysregulation
Objective: Investigate a role for GBA in accelerating the spread of protein aggregates via extracellular vesicles (EVs). Background: Parkinson’s disease (PD) progression correlates with temporo-spatial…A novel peptide reduces α-synuclein levels and neurodegeneration in cell, invertebrate, and mammalian models of Parkinson’s disease
Objective: To identify and test the effectiveness of a novel peptide to reduce α-synuclein levels and neurodegeneration in cell and animal models of Parkinson’s disease…Diagnostic value of vagus nerve ultrasound in Parkinson’s disease
Objective: To detect by the ultrasound (US) the possible presence of vagus nerve atrophy in patients with PD and its relation to severity of motor,…Altered interhemispheric synchrony in Parkinson’s disease patients with levodopa-induced dyskinesias
Objective: Our investigation aimed to explore interhemispheric functional alterations and its corresponding morphological synchronization changes. Background: Levodopa-induced dyskinesias are common motor complication of Parkinson’s disease…Disrupted functional brain connectome at the early non-freezing stage of Parkinson’s disease patients with freezing of gait
Objective: To investigate topological organization of the functional brain connectome at the early non-freezing stage of Parkinson’s disease (PD) patients with freezing of gait (FOG).…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.