In vivo imaging of presynaptic terminal loss in early Parkinson’s disease
Objective: To determine the magnitude and anatomical extent of presynaptic terminal damage in early Parkinson’s disease (PD) in vivo, we performed a PET study with…Improvement for Gait Disorders in Parkinson’s Disease Through Novel Comprehensive Treatment (IMPROVE study): A Prospective, Open-label, Randomized Controlled Clinical Trial
Objective: We conducted a prospective, open-label, randomized controlled clinical trial (clinical trial identifier: ChiCTR1900023466) to evaluate the effects of different combinations of comprehensive treatment on…Effect of home-based functional training program on enhancing gross and fine upper extremity function in people with Parkinson’s disease – a randomized controlled trial
Objective: The present study aimed to examine the effect of functional training on enhancing the gross and fine upper limb extremity function in people with…Rapid on-time onset and sustained improvements in motor states throughout the day following treatment with levodopa/carbidopa intestinal gel (LCIG) vs immediate-release levodopa/carbidopa oral capsules (LCIR)
Objective: To assess the speed of on-time onset and characterize the patterns of motor states throughout the day in advanced Parkinson’s disease patients treated with…Apomorphine Sublingual Film for On-Demand Treatment of “OFF” Episodes in Patients With Parkinson’s Disease: Effect on MDS-UPDRS Part III Subdomains
Objective: Evaluate effect of apomorphine sublingual film (APL-130277; APL) as an on-demand treatment of “OFF” episodes in patients with Parkinson’s disease (PD) on MDS-UPDRS Part…The Cognitive Training In Parkinson Study (COGTIPS), a randomized controlled trial
Objective: In this randomized controlled trial [1], our objective was to assess the effect of online home-based cognitive training on objective cognitive functioning and subjective…Can we customize tune for asymmetric tremor with differentiated Deep brain stimulation frequencies?
Objective: We aimed to display if differentiated frequency can improve the tremor in patients with STN-DBS. Background: Subthalamic deep brain stimulation (STN-DBS) is the best…Opicapone’s added benefit as a first-line adjunctive therapy to levodopa and when used promptly in the motor fluctuations spectrum of Parkinson’s disease: a post-hoc analysis of BIPARK-I and II
Objective: To evaluate opicapone (OPC) in Parkinson’s disease (PD) patients with motor fluctuations according to disease- and therapy-related characteristics. Background: OPC, a once-daily catechol-O-methyltransferase inhibitor,…Comparing the effects of rosemary and selegiline on behavioral symptoms of Parkinson’s animal model in mice
Objective: Parkinson is from common disorders of central nervous system and the second disease in neurodegenerative diseases which occurs in 1% of people over the…High Satisfaction and Improved Quality of Life with Rock Steady Boxing in Parkinson’s Disease
Objective: To compare demographics, self-reported symptom burden, Health-Related Quality of Life (HRQL), and Exercise Self-Efficacy (ESE) between Rock Steady Boxing (RSB) participants and non-participants. Background:…
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