Multiplex biomarker discovery for diagnostic and progression markers for Parkinson’s disease with the proximity extension assay technology on inflammation-related analytes
Objective: To identify diagnostic and progression biomarkers in the longitudinal DeNoPa cohort of (at enrolment) de novo Parkinson’s disease (PD) and healthy controls (HC) using…L-DOPA treatment in N2a cells stimulates neuromelanin biosynthesis: Using a novel in vitro model to examine the effect of iron and light on neuromelanin production
Objective: Naturally-occuring quantities of in vivo neuromelanin (NM) are low, and the collection of NM from tissue involves laborious extraction and isolation. Thus, in vitro…The feasibility of detailed phenotyping of muscle mitochondrial respiratory chain function and content in Parkinson’s disease
Objective: We aimed to determine: 1) the feasibility of obtaining and characterising skeletal muscle; and 2) if muscle mitochondrial respiratory chain (MRC) function and content…Sex differences on dynamic functional connectivity in Parkinson’s disease and healthy controls
Objective: The main objective was to evaluate the influence of sex in time-varying functional connectivity (FC) characteristics in Parkinson’s disease (PD) patients and healthy adults…Magnetic Property Characterization of Deep Gray Matters in Patients with Alzheimer’s diseases, Dementia with Lewy Bodies and Parkinson’s Disease Dementia using Quantitative Susceptibility Mapping
Objective: The purpose of this study was to characterize magnetic properties of deep gray matters in Alzheimer's diseases (AD), dementia with Lewy bodies (DLB) and…Parkinson’s Disease Exhibits Longitudinal Increases in beta-Amyloid in the Striatum and Cingulate Gyrus
Objective: To identify longitudinal patterns of beta-amyloid(Ab) accumulation in Parkinson's disease (PD) through the use of Pittsburgh Compound B (PiB) Positron Emission Tomography imaging in…Resting State Functional and Structural Connectivity Changes of Cerebellum Basal Ganglia Interconnecting Network in Parkinson’s Disease
Objective: 1. Identify the role of Cerebellum Basal Ganglia structural and functional connectivity changes in Healthy subjects Vs PD patients. 2. Establish Cerebellum Basal Ganglia…Brain cholinergic dysfunction in patients with isolated REM sleep behavior disorder: A clinical and 11C-Donepezil PET follow-up study
Objective: In this follow-up study, we aimed to explore the temporal changes in brain acetylcholinesterase activity and cognitive function of iRBD patients. Background: Isolated REM…Abnormal Cerebral Glucose Metabolism and Dopaminergic Dysfunction in Patients with Parkinson’s Disease with Bilateral Onset
Objective: To explore the characteristics of the abnormal cerebral glucose metabolism and dopamine distribution in patients with Parkinson's disease (PD) with bilateral onset. Background: PD is…Chronic wireless streaming of pallidal and cortical recordings in Parkinson’s disease over 1000 hours at home
Objective: To investigate pallidal and cortical activity associated with motor signs in Parkinson’s disease (PD), by wireless transmission from an implantable bidirectional interface at home…
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