Alpha-synuclein and Amyloid beta peptide 1-42 in Parkinson’s disease and parkinsonian plus syndrome cohorts
Objective: To evaluate the serum levels of α-synuclein (α-syn) and Amyloid β 1-42 (Aβ1-42) in the patients of Parkinson’s disease (PD), progressive supranuclear palsy (PSP)…Gut Microbiota in Parkinson’s disease: influences of device-assisted therapies
Objective: To determine the temporal stability of gut microbiota (GM) profiles around the acute establishment of advanced Parkinson's disease (PD) therapies and describe resulting alterations in…Detection of alpha-synuclein aggregation from submandibular and esophageal tissue of patients with synucleinopathies
Objective: Utilize cyclic amplification methods to facilitate detection of aggregation prone forms of a-syn from submandibular or esophageal tissue of patients with syncleinopathies. Background: In…Functional connectivity traits in Parkinson’s disease mild cognitive impairment
Objective: Our objective is to assess functional networks in PD mild cognitive impairment (PD-MCI) and their contribution to global connectivity combining Connectome ICA (connICA) and…Deep learning-based automatic nigrosome 1 segmentation on 3T susceptibility-weighted MRI
Objective: The aim of this study was to develop a deep learning-based system for automatic nigrosome 1 segmentation on susceptibility-weighted imaging (SWI) from 3T magnetic…Parkinson’s Disease Exhibits Longitudinal Increases in beta-Amyloid in the Striatum and Cingulate Gyrus
Objective: To identify longitudinal patterns of beta-amyloid(Ab) accumulation in Parkinson's disease (PD) through the use of Pittsburgh Compound B (PiB) Positron Emission Tomography imaging in…Resting State Functional and Structural Connectivity Changes of Cerebellum Basal Ganglia Interconnecting Network in Parkinson’s Disease
Objective: 1. Identify the role of Cerebellum Basal Ganglia structural and functional connectivity changes in Healthy subjects Vs PD patients. 2. Establish Cerebellum Basal Ganglia…Brain cholinergic dysfunction in patients with isolated REM sleep behavior disorder: A clinical and 11C-Donepezil PET follow-up study
Objective: In this follow-up study, we aimed to explore the temporal changes in brain acetylcholinesterase activity and cognitive function of iRBD patients. Background: Isolated REM…Abnormal Cerebral Glucose Metabolism and Dopaminergic Dysfunction in Patients with Parkinson’s Disease with Bilateral Onset
Objective: To explore the characteristics of the abnormal cerebral glucose metabolism and dopamine distribution in patients with Parkinson's disease (PD) with bilateral onset. Background: PD is…Chronic wireless streaming of pallidal and cortical recordings in Parkinson’s disease over 1000 hours at home
Objective: To investigate pallidal and cortical activity associated with motor signs in Parkinson’s disease (PD), by wireless transmission from an implantable bidirectional interface at home…
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