Fine-grained prediction of Huntington’s disease stage using a meta-model approach
Objective: We developed a machine learning (ML) framework that facilitates prediction of individual-level Huntington’s disease (HD) stage. The proposed meta-model approach classifies participants according to…Development of the Huntington’s Disease Integrated Staging System (HD-ISS)
Objective: To propose a new HD framework, referred to as the HD-ISS, that comprises an HD biological research definition and evidence-based staging centered on prognostic…Lingual myoclonus associated with brain metastasis located near the primary tongue motor cortex: case report.
Objective: To report a case of a patient with lung cancer who developed lingual myoclonus, revealing brain metastases. Background: Lingual myoclonus has been described associated…TREMOR-LYTIC AND PREFRONTO-CORTICAL PROPERTIES OF Nigella sativa OIL IN PHENOL-INDUCED MICE MODELS OF ESSENTIAL TREMOR
Objective: This work assessed the tremor-lytic and prefronto-cortical properties of Nigella sativa oil in phenol-induced mice models of essential tremor. Background: Essential tremor is a…The Development of a Parkinson’s Disease Biomarker Inventory Dashboard
Objective: There is an urgent need for validated biofluid biomarkers in Parkinson’s disease (PD) drug development. Under the auspices of the Critical Path for Parkinson’s…TNF-α Mediated Neuroinflammation Associated with UPRmt in Kaolin Induced Hydrocephalus Mouse Model
Objective: To identify the association between tumor necrosis factor-α (TNF-α) signaling and mitochondrial unfolded protein responses (UPRmt) against ventricular expansion, we used the kaolin induced…Precision Medicine in Neurodegeneration associated with Pantothenate kinase (PKAN) , its possible?
Objective: The objective of this review is to open a discussion on the usefulness of the use of cell models derived from patients as a…Palliative care evaluation for movement disorders during COVID-19: Using Tele neurology to provide real-time care for an at risk Veterans Population.
Objective: To deliver palliative care via telemedicine in a video format to veterans at risk with movement disorders in need of palliative care in the…The OCEAN (OpiCapone Effect on motor fluctuations and associated pAiN) study in Parkinson’s disease: design and rationale of a randomized double-blind placebo-controlled trial
Objective: To evaluate if treatment with opicapone (OPC) in patients with Parkinson’s disease (PD) improves pain related to end-of-dose fluctuations, consequently improving patients’ well-being. Background:…Overcoming clinical research challenges during a pandemic: selection and implementation of digital phenotyping solutions in a natural history study of G2019S LRRK2 Parkinson’s disease.
Objective: To identify candidate wearable devices or digital solutions suitable for conducting the Timed Up and Go (TUG) test and evaluate real-world performance remotely during…
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