Investigating LRRK2 and GBA genetic variability in underrepresented populations
Objective: To address the pressing need through promoting collaborative translational work evaluating genetic signatures in Latinx and African-American (AA) participants with and without Parkinson’s disease…Genotype-phenotype relations for GBA as a Parkinson’s disease risk factor gene: MDSGene Systematic Review
Objective: To provide a comprehensive and systematic review of genotype-phenotype associations of GBA variants for Parkinson’s disease (PD). Background: Biallelic pathogenic variants in the glucocerebrosidase gene (GBA) cause Gaucher disease (GD).…Rapamycin attenuates nigral and hippocampal alpha-synuclein accumulation in AAV-mediated alpha-synuclein overexpression model of Parkinson’s disease
Objective: To examine the possible neurorestorative effects of chronic rapamycin treatment in AAV-mediated alpha-synuclein (a-syn) overexpression model of Parkinson’s disease (PD), designed to induce hippocampal…VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease
Objective: To establish the pathogenic effects of the PD-causing VPS35 D620N mutation in vivo and address possible underlying mechanisms. Background: D620N mutation in the vacuolar…EVALUATION OF THE ABSENCE OF NIGROSOME 1 BY MAGNETIC RESONANCE 3 TESLA IN PARKINSON’S DISEASE ACCORDING TO TIME OF EVOLUTION TO DIAGNOSIS VS MESENCEPHALIC ECOGRAPHY.
Objective: The primary objective was to evaluate the absence of nigrosome 1 in 3TMRI in a group of patients with PD according to their evolutionary…EVOLUTION OF PARKINSON’S DISEASE IN PATIENTS WITH ESSENTIAL TREMOR: CLINICAL AND NEUROIMAGING ASPECTS
Objective: Analyze the result of the SPECT-TRODAT image exam in patients with ET and to evaluate the predictive value of a possible evolution to the…Parkinson Disease with, but not without, Cognitive Decline Reveals Advanced Brain Aging
Objective: To investigate “brain age” in Parkinson disease (PD) with and without cognitive decline, and its correlation with motor and cognitive performance. Background: Although brain…Dissociated longitudinal evolution of limbic serotonergic and striatal dopaminergic and serotonergic pathology in apathetic and non-apathetic patients in early Parkinson’s disease
Objective: To investigate the longitudinal changes in striatal and extra-striatal dopaminergic and serotonergic innervation in apathetic and non-apathetic patients during the five years after the…Brainstem planimetry in Parkinson’s disease with REM behaviour disorder.
Objective: To investigate the association between brainstem planimetry and REM behaviour disorder (RBD) in de novo Parkinson’s disease (PD). Background: RBD is associated with a…Locus coeruleus degeneration associated with less levodopa responsiveness in Parkinson’s Disease
Objective: We aimed to explore the relationship between LC degeneration and levodopa responsiveness in Parkinson’s Disease (PD) patients in vivo. Background: Widely divergent responsiveness of…
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