α-synuclein expression is not mediated by β2-adrenoreceptor modulation in human dopaminergic cells
Objective: Modulation of the β2-adrenoreceptor (also called the β2-adrenergic receptor or β2-adrenoceptor) has been reported to regulate SNCA expression. We sought to determine the expression…Analysis of Amantadine formulations for OFF and Dyskinesia in Parkinson Disease
Objective: Evaluate the effects of amantadine formulations on the treatment of OFF and dyskinesia in Parkinson’s patients. Background: There are currently three formulations of amantadine…Real-world characteristics of advanced Parkinson’s disease patients initiating carbidopa/levodopa enteral suspension
Objective: To describe the real-world characteristics of advanced Parkinson’s disease (APD) patients initiating carbidopa/levodopa enteral suspension (CLES) therapy in USA Background: CLES is an FDA…Inhibition of GluN2D-containing NMDA receptors alleviates the loss of dopaminergic neurons and behavioral deficits in 6-OHDA-induced model of Parkinson’s disease
Objective: The aim of this study is to explore whether the inhibition of GluN2D-containing NMDA receptors (NMDAR2D) can delay the pathological manifestations of Parkinson's disease…Longitudinal 18F-PBR06 (TSPO) and Volumetric MR Imaging as Pharmacodynamic Endpoints for MSA – Ongoing Investigator Sponsored Trial of Verdiperstat
Objective: In multiple system atrophy (MSA) patients to: 1) evaluate 18F-PBR06 positron emission tomography (PET) for longitudinal assessment of 18-kilodalton-translocator protein (TSPO) binding; 2) assess…Neuroimaging associations to gait impairments in progressive supranuclear palsy
Objective: The aim of this study was to determine how multimodal imaging biomarkers were related to abnormalities in three-dimensional motion-based gait and balance measurements in…The pandemic stress impact on disease progression in COVID-19 seronegative patients with idiopathic Parkinson’s Disease.
Objective: To investigate the impact of chronic stress (CS) induced by the present pandemic on the progression rates of motor and cognitive impairment, on neuro-inflammatory…Could Gender have an effect on Clinical and Transcranial Parenchymal Ultrasound Findings in Parkinson’s disease Patients?
Objective: We aimed to explore the possible differences between males and females as regarding motor, non-motor, depressive symptoms, cognitive functions and Transcranial Parenchymal Ultrasound (TCS)…Investigation of the consultation status and clinical symptoms of patients with Parkinson’s disease after the spread of COVID-19
Objective: This study investigated the consultation status and clinical symptoms of patients with Parkinson’s disease (PD) after the coronavirus disease 2019 (COVID-19) pandemic. Background: Due…Central and Peripheral neurological manifestations of COVID-19 in a cohort of patients with Parkinson’s disease.
Objective: To describe central and peripheral neurological manifestations in patients with COVID-19 and Parkinson’s disease. Background: COVID-19 is associated with central and peripheral neurological manifestations.…
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