Quantity detection of Substantia nigra hyperechogenicity based on digital image analysis for diagnosing Parkinson’s disease
Objective: We aimed to apply digital analysis to quantify hyperechogenicity of Substantia nigra, and explore its clinical value for the diagnosis of PD. Background: Increased…Multimodal MRI assessment of the substantia nigra in premotor and motor stages of parkinsonism
Objective: To investigate substantia nigra (SN) MRI abnormalities through Neuromelanin (NM) and diffusion MRI (dMRI) with Neurite Orientation Dispersion and Density Index (NODDI) in the…Cross-cultural validation of the Cebuano version of a screening questionnaire for Parkinson’s Disease
Objective: To determine the validity of the Cebuano version of a PD screening questionnaire Background: In the Philippines, actual prevalence of Parkinson’s Disease (PD) is…Selection of clinical doses for SBT101, an AAV9-hABCD1 vector for the treatment of adrenomyeloneuropathy
Objective: To inform selection of doses of SBT101 for a first-in-human clinical study. SBT101 is an adeno-associated virus serotype 9 (AAV9)-based gene therapy candidate intended…Functional validation of a mitochondria-specific polygenic risk score in patient-based models for stratification of idiopathic Parkinson’s disease
Objective: The overall objective of this project is to gain essential knowledge on the contribution of genetic variability in nuclear-encoded mitochondrial proteins to idiopathic Parkinson’s…Biomarker based on natural language processing methods to detect the stages of Parkinson’s disease through electroencephalography
Objective: Stage classification of Parkinson's Disease (PD) through Electroencephalograms (EEGs) using Natural Language Processing (NLP) techniques. Background: PD is a neurodegenerative disease mainly characterized by…Effect of levodopa-carbidopa intestinal gel on lower urinary tract symptoms in Parkinson’s disease: an Urodynamic study
Objective: Here we report urodynamic results before and six months after LCIG treatment in PD patients suffering from LUTS. Background: Dopaminergic transmission plays a key…DystoniaBoTXNet: A Deep Learning Platform for Predictive Outcome of Botulinum Toxin Treatment in Isolated Dystonia
Objective: To develop and validate an objective measure of the botulinum toxin treatment outcome in isolated dystonia. Background: Dystonia is characterized by abnormal, often painful,…Duration of continuous “Good On” intervals and number of motor fluctuations after treatment with IPX203 vs immediate-release carbidopa-levodopa in Parkinson’s disease patients with motor fluctuations.
Objective: To compare the duration of continuous “On” without troublesome dyskinesia (“Good On”) intervals and number of motor fluctuations per day in Parkinson’s disease (PD)…Characterization of nociplastic pains in Parkinson’s disease (PD) with the PD pain classification system (PD-PCS)
Objective: To describe the new category of nociplastic pain (NP). We defined Parkinson's disease (PD)-related pains and allocated them to a mechanistic category by using the…
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