Alpha-synuclein fibril-based mouse model of REM sleep behavior disorder as a prodrome of synucleinopathy
Objective: To investigate whether in wild-type mice, inoculation of α-synuclein (aSyn) preformed fibrils (PFFs) into the sublaterodorsal tegmental nucleus (SLD), a core structure associated with…Visuospatial deficits characterize Pisa syndrome and not Camptocormia in Parkinson’s disease
Objective: We performed a multicenter, case-control study with the aim to analyze cognitive differences between parkinsonian patients with Pisa syndrome or camptocormia and matched controls…Impact of the delayed diagnosis in the prognosis of Parkinson’s disease.
Objective: To evaluate the difference of motor and non-motor dysfunction, and quality of life in Parkinson’s disease (PD) patients with and without delayed diagnosis. Background:…Structural MRI features of glucocerebrosidase (GBA)-associated Parkinson’s disease
Objective: To compare structural differences in brain magnetic resonance imaging (MRI) between Glucocerebrosidase (GBA) mutation carriers with Parkinson’s disease (PD-GBA) vs non-mutation carriers. Background: PD-GBA…Cerebellar and other motor symptoms in Huntington’s Disease: A multiple scale correlation study
Objective: To describe the cerebellar symptoms and other accompanying movement disorders in Huntington's Disease (HD). Background: HD is a pathological entity whose etiological substrate is…Multi-modal MRI features and their relationship with clinical scales in Parkinson disease and Atypical Parkinsonian Syndromes
Objective: To compare MRI sings and volumetric measurements in Parkinson disease (PD), Progressive Supranuclear Palsy (PSP), and Multiple System Atrophy (MSA) and their relationship with…DBS Experience In A Pediatric Neurowilson Case
Objective: I have chosen this case to demonstrate an atypical presentation of Neuro-Wilson disease without a prominent hepatic involvement. I have also aimed to call…Bullous skin lesions following introduction of safinamide in a woman with Parkinson’s disease
Objective: To present the case of a woman with Parkinson’s disease (PD) who developed pemphigoid-like skin lesions after being started on safinamide therapy. Background: Safinamide…Cognitive and Functional Trajectories in Prediagnostic Parkinson’s Disease
Objective: To describe prediagnostic cognitive and functional trajectories in Parkinson’s Disease (PD). Background: Cognitive and functional decline is typically considered a late manifestation of PD.…Blaming neuromelanin for Parkinson’s disease: time-dependent tyrosinase overexpression drives endogenous synucleinopathy in non-human primates
Objective: Development and characterization of a novel non-human primate model of Parkinson’s disease based on the AAV-mediated forced expression of human tyrosinase Background: Although neuromelanin…
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