Neuroprotective effects of Ibudilast, a Phosphodiesterase IV inhibitor in mouse model of Parkinson’s disease
Objective: In the present study, we examined neuroprotective effects, if any, of IBD drug, a inhibitor of the phosphodiesterase IV in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse…The brain-age framework in Parkinson’s disease: evaluating MRI morphometry and sex-dimorphism
Objective: We aimed to develop an MRI brain-age prediction (BAP) model to evaluate differences between Parkinson’s disease (PD) and healthy controls (HC). We further evaluated…Cortical responses evoked by stimulation of the subthalamic nucleus for intraoperative target determination in deep brain stimulation
Objective: 1. Method development to routinely determine cortical responses evoked by stimulation of the subthalamic nucleus (STN-EP) during intraoperative electrode placement for STN deep brain…C-SURF: DBS programming using probabilistic maps as an efficient new approach to treat patients with dystonia: the results of a feasibility study.
Objective: To evaluate the clinical potential of a novel computer-guided prediction of optimal stimulation settings for pallidal DBS for the treatment of motor symptoms of…Automated scoring of REM sleep without atonia using the open-source software RBDtector
Objective: To facilitate quantification of REM sleep without atonia (RSWA) and thereby identify patients with rapid eye movement (REM) sleep behaviour disorder (RBD). Background: RBD…Addressing pathological alpha-synuclein aggregation using a small molecule strategy
Objective: The discovery of cell-permeable, orally bioavailable and brain penetrant small molecules with the potential of inhibiting aggregation and intracellular accumulation of pathological alpha-synuclein (a-syn)…Can we add whey protein supplementation in patients with Parkinson’s disease without interfering with levodopa response?
Objective: The main endpoint of the study was to evaluate if a daily intake of whey protein-based dietary supplement causes a worse response to levodopa…NIMHANS Neuropsychological Battery for Elderly in Parkinson’s disease patients: Validation and diagnosis using MDS PD-MCI task force criteria in Indian population
Objective: To validate NIMHANS Neuropsychological Battery for Elderly( NNB-E) and evaluate cognitive impairment in Parkinson's disease (PD) patients in comparison with healthy controls. Background: Cognitive…Hyperkinetic movement disorder following Covid: A Temporal corelation or Coincidental ?
Objective: Hypokinetic movement disorder and parkinsonian like picture has been well described in literature but hyperkinetic movements are extremely rare and less highlighted in global…The anti-alpha-synuclein antibody Lu AF82422 binds to pathological alpha-synuclein species from human brains and inhibits seeded alpha-synuclein aggregation
Objective: Lu AF82422 is a human IgG1 monoclonal antibody that binds all known forms of alpha-synuclein (aSyn), including monomeric, aggregated and truncated. Data are presented…
- « Previous Page
- 1
- …
- 140
- 141
- 142
- 143
- 144
- …
- 153
- Next Page »