Mutational effects of LRRK2 I1371V in astrocytes derived from patient specific iPSCs
Objective: To identify the LRRK2 I1371V mutational effects on astroglial biology involving glutamate metabolism and glutathione machinery. Background: The underlying cause of most of the familial…Hemichorea-hemiballismus syndrome without damage to the subthalamic nucleus?
Objective: Discuss a case of Non-ketotic hyperglycemia hemiballismus hemichorea that preserves the subthalamic nucleus (STN). Background: Non-ketotic hyperglycemia hemiballismus hemichorea is a pathology characterized by…Successful treatment of Stiff Person Syndrome with botulinum toxin
Objective: Describe a case of Stiff Person Syndrome (SPS) treated with botulinum toxin injection and alert to the utility of botulinum toxin in this disorder.…Effect of KW-6356, a novel adenosine A2A receptor antagonist/inverse agonist, on motor and non-motor symptoms in Parkinson’s disease patients as an adjunct to levodopa therapy: Results of Phase 2b study
Objective: To evaluate the efficacy and safety of KW-6356 in Parkinson’s disease (PD) patients with levodopa therapy, irrespective of the presence of wearing-off (WO). Background:…Use of apomorphine infusion pump in the elderly population : a 5 years follw up study on efficacy, safety and tolerability in a cohort bases study
Objective: Evaluate the efficacy, tolerability and safety of subcutaneous apomorphine infusion in elderly patients with advanced Parkinson's disease in a five years follow up cohort. Background: Continuous infusion by subcutaneous apomorphine pump has…Testamentary Capacity Assessment Tool (TCAT): An update report
Objective: The present study reviews all studies about TCAT and its use in clinical settings, as well as its validation in different cultures. Background: TCAT…Predictors of the change in burden and strain among caregivers of Parkinson’s disease patients
Objective: The aim of the present study was to analyze the change in burden and strain after a 2-year follow-up in a cohort of caregivers…Safety and Efficacy of unilaterally Focused Ultrasound Subthalamotomy in Early Parkinson´s Disease: The EARLY FOCUS I Study
Objective: To assess the safety and efficacy of unilateral FUS subthalamotomy in early PD patients. Background: FUS subthalamotomy is feasible and therapeutically effective in Parkinson´s…Globus pallidus as a neurosurgical target in the management of levodopa-induced dyskinesias
Objective: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the development of motor symptoms, as well as some non-motor changes. Symptomatic treatment of PD…Caregiver burden and quality of life in late stage Parkinson’s disease
Objective: To describe and assess factors associated with informal caregiver quality of life (QoL) in late stage Parkinson’s disease (PD). Background: In the late stage…
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