Bis(monoacylglycerol) phosphate levels are elevated at baseline in carriers of pathogenic variants in LRRK2 and GBA1 and do not predict progression of PD in PPMI cohorts
Objective: To assess: (a) effects of LRRK2 and GBA1 pathogenic variants on baseline urinary bis(monoacylglycerol) phosphate (BMP) levels in those with and without Parkinson’s disease…Factors associated with progression of Parkinson’s disease and deterioration in quality of life: Results of J-FIRST, a 1-year observational study
Objective: To investigate whether individual non-motor symptoms (NMSs) are associated with overall NMS or quality of life (QOL) in Parkinson's disease (PD). Background: Worsening motor…Catatonic Syndrome in Covid-19 Infection: Medication Treatment or Hyperbaric Oxygen Therapy.
Objective: Catatonic syndrome, or catatonia (from other Greek κατατείνω - “stretch, strain”), is a psychopathological syndrome (a group of symptoms), the main clinical manifestation of…Prevalence and distribution of disease-associated alpha-synuclein in a homeless population
Objective: To study the prevalence and distribution of pathological alpha-synuclein deposition, throughout the central and peripheral nervous systems, in a homeless population. Background: The homeless…Vodobatinib, a potent, orally bioavailable brain-penetrating inhibitor of c-Abl as a potential neuroprotective agent for the treatment of Parkinson’s Disease
Objective: To compare and contrast nilotinib and vodobatinib regarding efficacy, brain penetration, and safety. Background: Preclinical evidence suggests that c-Abl is critical for pathogenesis of…Atypical parkinsonism presenting in late 60s in an individual with GCH1 mutation
Objective: To report a case of possible comorbid tau and Lewy pathology in an individual with a GCH1 mutation. Background: A 69-year-old man developed atypical parkinsonism…Occlusal Stabilization Appliance on treatment of cervical dystonia
Objective: To evaluate the effect of occlusal stabilization appliance on cervical dystonia. Background: Cervical dystonia is a contraction of the neck muscles that causes movement…Is motor symptoms asymmetry a possible predictor of short-term motor outcome of bilateral STN-DBS in Parkinson’s disease?
Objective: To evaluate if the body side of motor symptoms onset may predict the short-term motor outcome of bilateral subthalamic nucleus deep brain stimulation (STN-DBS)…Lower-limb dystonia as an explanation for freezing of gait responsive to cueing in Parkinson’s Disease
Objective: We aimed to search the literature for a potential association between freezing of gait (FOG) with cueing and dystonia with sensory tricks in Parkinson’s…Impaired behavioral proactive inhibitory control and flexibility in a mouse model of early Parkinson’s disease
Objective: The aim of our study is to address the impact of a moderate nigrostriatal DA lesion induced by 6-hydroxydopamine (6-OHDA) injection into the dorsomedial…
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