Mortality in Parkinson’s patients following Covid19 infection in the second wave of the pandemic
Objective: To analyze causes of mortality and death certification in Parkinson’s disease patients who had SARS- CoV2 in Reading, West Berkshire, United Kingdom (UK) Background:…A Narrative Review of Literature on Exercise Therapy and Cognitive Impairment in Individuals with Parkinson’s Disease: The Role of Epigenetics as a Mediator.
Objective: This narrative review explored the potential role of exercise as an epigenetic mediator of cognitive function in people with PD and the possible underlying…A user experience evaluation of a Huntington’s disease app: Implications for mobile-first design
Objective: To evaluate usability, functionality, and interface design to inform improvements for future iterations of the GEORGE® app for use in research. Background: GEORGE® is…Late-onset cerebellar ataxia: case report of a new CNV on TTBK2 gene as possible cause of SCA-11
Objective: To describe a case of spinocerebellar ataxia type 11 caused by the copy number variant 43008859_43075833 on the TKKB2 gene Background: The spinocerebellar ataxias…Robust methods for missing covariates in longitudinal studies with application to biomarker research in Parkinson’s disease dementia
Objective: We propose a nonparametric method for handling different types of missing covariates in longitudinal studies. We show that the proposed method outperforms multiple standard…A Report from Japan on Initial Experiences with Adaptive Deep Brain Stimulation Therapy for Patients with Advanced Parkinson’s Disease
Objective: Here we present our initial experience with deep brain stimulation therapy (DBS) for Parkinson's disease (PD) using the closed-loop system. Background: Although DBS is…Microglial activation facilitates alpha synuclein propagation and neurodegeneration in αSyn preformed fibrils (PFF)-injected PD mouse model
Objective: To evaluate whether microglial activation aggravates synucleinopathy progression in Parkinson's disease (PD) mouse model. Background: Alpha-synuclein (αSyn) accumulation underlay the main pathological process of…Co-contractions as a Biomarker for DBS Efficacy in Dystonia
Objective: Deep brain stimulation of the globus pallidus interna (GPi-DBS) is a treatment option for medication-refractory dystonia. However, the clinical outcome after DBS-GPi is variable,…APEG-PCL Nanoparticles Containing Rifampicin Target Dopaminergic Neurons to reduce α-synuclein aggregation
Objective: There were accumulating evidence proving that rifampicin could protect neurons from apoptosis in Parkinson's disease in-vitro model by regulating SUMO modification of α-synuclein. However,…Delayed Osmotic Demyelination Syndrome- An Evolving Spectrum
Objective: To report a case of osmotic demyelination syndrome (ODS) with continuing clinical and radiological worsening beyond its previously established temporal course. Background: ODS is…
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