Cognitive-motor tests markedly increase the diagnostic rate of “On-meds” freezing of gait in Parkinson’s disease during clinical visits
Objective: To develop a testing and recording system that can reliably increase the rate of diagnosing freezing of gait (FOG) in patients living with Parkinson’s…Subcortical Atrophy and Fall Risk in Parkinson’s Disease
Objective: To evaluate the relationship between various measures of subcortical atrophy with fall risk in PD. Background: Falls occur in nearly 70% of people with…CAREGIVERS BURDEN IN CARING FOR PERSONS WITH PARKINSON’S DISEASE: A SURVEY FROM A TEACHING HOSPITAL IN GHANA
Objective: To determine the burden of caregivers in caring for persons with Parkinson’s disease (PD) and establish the relationship between the burden of care and…Utility of Seed Amplification Assay for Detecting α-synuclein in Formalin-Fixed Paraffin Embedded Skin Samples in Parkinson’s Disease
Objective: To determine the sensitivity for Parkinson’s disease (PD) diagnosis of seed amplification assay (SAA) for α-synuclein (α-syn) in formalin-fixed paraffin-embedded (FFPE) skin specimens and…Preclinical Characterization of Suvecaltamide for Essential Tremor
Objective: To characterize the in vitro T-type calcium (CaV3) channel target pharmacology and in vivo anti-tremor profile of suvecaltamide (JZP385, CX-8998). Background: CaV3 channels, a…The level of glial neurotrophic factor in blood plasma depending on the stage of Parkinson’s disease
Objective: To study the level of glial neurotrophic disease in blood plasma in patients with Parkinson's disease (PD) depending on the stage Background: Parkinson's disease…Investigation of Modifiers of β-Glucocerebrosidase in Cell Models of Parkinson’s Disease
Objective: We firstly aim to identify modifiers of β-glucocerebrosidase (GCase) activity and expression in Parkinson’s disease (PD) relevant cell models. We secondly aim to ascertain…Amantadine Delayed Release/Extended Release Capsules Reduce the Proportion of the Day Spent in “BAD” Time (ON with Troublesome Dyskinesia or OFF): Analysis of Phase 3 Trial Data
Objective: To evaluate the effect of treatment with amantadine delayed release/extended release (AMT DR/ER) vs. placebo on the proportion of the waking day spent in…A One-year follow-up study of effects of voltage/frequency Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) adjustments on speech intelligibility in Parkinson’s Disease (PD)
Objective: To assess the relationship between along-1-year stimulation voltage(V)/frequency(F) adjustments and speech intelligibility (SI) in PD patients treated with STN-DBS. Background: Low V/F stimulation improves…Continuous circadian intracerebroventricular administration of anaerobically preserved dopamine greatly reduces severe L-dopa-related complications in Parkinson’s disease
Objective: We aim to demonstrate the safety and efficacy of continuous circadian intracerebroventricular (i.c.v.) administration of anaerobic-dopamine (A-dopamine) to reduce the L-dopa-related complications (LDRC) in…
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