RNA editing contributes to the inflammatory astrocytic response in Parkinson’s disease.
Objective: 1) Using an IPSC derived cell model to explore astrocytic responses alone and cocultured neurons to alpha-synuclein oligomer (αsynO) treatment.2) Determine the extent to…Combined GWAS of Dementia with Lewy Bodies, REM-Sleep Behavior Disorder, Parkinson’s Disease and Alzheimer’s Disease
Objective: To identify genetic variants that are either shared between or specific for Dementia with Lewy Bodies (DLB), REM Behavior Disorder (RBD), Parkinson’s disease (PD)…Combination of clinical and gait measures to classify fallers and non-fallers in Parkinson’s disease
Objective: To identify clinical and objective gait measures that best discriminate fallers from non-fallers in Parkinson’s disease (PD), with suggestions of optimal cutoff scores Background:…Does baseline expectation of benefit predict outcome in SURE-PD3, a Randomized, Double-Blind, Placebo-Controlled, Phase III trial of Inosine in Parkinson’s disease?
Objective: To evaluate the association of patient-reported baseline expectation with efficacy outcomes in a randomized placebo-controlled trial (RCT) in PD. Background: Expectation of benefit can…Olfactory neurons’ Substance P is highly expressed in Parkinson’s disease reflecting gastrointestinal dysfunction
Objective: To elucidate the role of Substance P in PD through molecular characterization of patients’ olfactory neurons. Background: Substance P is a neuropeptide largely expressed…Parkinson’s disease-associated psychosis in a Brazilian sample: worse cognitive outcomes, higher LEDD and longer disease duration.
Objective: To describe the prevalence of Parkinson's Disease (PD) associated psychosis (PDAP) at a Brazilian movement disorders outpatient and to evaluate its associated factors. Background:…Huntington’s disease-like 2 phenotypes: a case series from a Brazilian referral center
Objective: To describe the clinical phenotypes of Huntington’s disease-like 2 patients in a referral movement disorders (MD) center in Brazil. Background: Huntington's disease-like 2 (HDL2)…Case of neuroferritinopathy with isolated dystonic leg cramps and normal neuroimaging
Objective: To describe a case of genetically proven neuroferritinopathy with isolated dystonic leg cramps and normal neuro-imaging. Background: Neuroferritinopathy(NF) is an autosomal dominant condition characterized…Subanesthetic infusion of ketamine produces long-term reduction in levodopa-induced dyskinesia and depression in individuals with Parkinson’s Disease
Objective: An open-label, dose-finding Phase I/II clinical trial was conducted to test safety and tolerability of low-dose ketamine infusion to treat levodopa-induced dyskinesia (LID), and…Computerized assessment of Handwriting in Parkinson’s Disease Before and After Dopaminergic Medication
Objective: Computerized assessment of dysgraphia to evaluate dopaminergic medication effects on the handwriting of newly diagnosed PD patients. Background: Dysgraphia is a common motor symptom…
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