Detecting Changes in Parkinson’s Motor Symptom Patterns Using Wearable Devices
Objective: Evaluate mobile application and wearable device for detecting clinically significant changes in Parkinson's motor symptoms. Background: Monitoring motor and non-motor symptoms in Parkinson's disease…Gender differences in non-motor fluctuations in Parkinson’s disease
Objective: To estimate the burden of NMF in PD patients and to evaluate the possible gender effect. Background: Non-motor symptoms (NMS) are commonly experienced by…Incidence and Predictors of Axial Postural Abnormalities in Parkinson disease: data from the PPMI cohort
Objective: We aim to evaluate the incidence of axial postural abnormalities in patients with Parkinson’s disease (PD) and analyze their demographic and clinical predictors. Background:…Preliminary results of the validation study of the Shame in Parkinson’s disease (SPARK) Scale
Objective: The goal of this study is to validate the Shame in PARKinson’s disease (SPARK) Scale [1] which identifies the presence, the extent and some…Pronounced Cervical Dystonia in Ataxia with Vitamin E Deficiency
Objective: Objective: To describe a case report of an atypical phenotype of ataxia with vitamin E deficiency (AVED) and marked cervical dystonia. Background: Background: AVED…Atypical parkinsonism syndromes: clinical presentations
Objective: Here, our aim was to identify the characteristics of atypical clinical presentations of atypical parkinsonism syndromes in our cohort and our secondary aim was…Validity and responsiveness of the EQ-5D-3L in Friedreich-Ataxia
Objective: The objective was to validate the well-established EQ-5D in Friedreich’s ataxia (FA). Background: Health-related quality of life (HRQoL) is increasingly researched in FA. The…Detecting clinical fluctuations in chronic biomarker recordings: experiences with chronic subthalamic peak beta band recordings in a large Parkinson’s disease patient cohort
Objective: Since the understanding of electrophysiological biomarker dynamics during every-day activities is crucial for adaptive deep brain stimulation (aDBS), this study aims to investigate characteristics…gender differences of fatigue and sleep characteristics in parkinson’s disease patients
Objective: to study the gender differences in fatigue and sleep characteristics in a cohort of Parkinson’s disease (PD) patients Background: Fatigue is a common problem…LRRK2 PROTAC® degrader molecules induce robust biomarker responses in preclinical in vivo pharmacology studies following acute and chronic oral dosing
Objective: Report on the non-clinical in vivo pharmacokinetic and pharmacodynamic biomarker response to PROteolysis TArgeting Chimera (PROTAC®) molecules designed to induce degradation of leucine rich…
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