Improvement in spasticity-associated dressing- and hygiene-related disability in adults following treatment with incobotulinumtoxinA: a pooled analysis
Objective: To evaluate impact of incobotulinumtoxinA (incoA) on dressing- and hygiene-related disability (DRE and HYG) in adults with upper-limb spasticity (ULS) based on pooled data…Free water neuro-imaging changes as the biomarker in new diagnosis of Wilson’s disease
Objective: The bi-tensor free water imaging may provide more specific information in detecting microstructural brain tissue alterations than conventional single tensor diffusion tensor imaging. The…High Intensity Interval Training for people with Parkinson’s disease: individual response patterns of (non-)motor symptoms and blood-based biomarkers – a crossover single-case experimental design
Objective: To quantify individual response patterns of motor symptoms to alternating exercise modalities, along non-motor functioning and blood biomarkers of neuroplasticity and neurodegeneration. Background: Physical…Safety of foslevodopa/foscarbidopa during optimization and maintenance treatment: Post hoc analysis of a phase 3, single-arm trial
Objective: Evaluate the frequency of adverse events over time with foslevodopa/foscarbidopa (LDP/CDP) in patients with advanced Parkinson’s disease (PD) in a phase 3, open-label safety…Reproductive life factors and sex hormones in post-menopausal female patients with Parkinson’s Disease
Objective: To deepen into sex-dependent mechanisms of Parkinson’s disease (PD) by analyzing the relationships between reproductive life factors, sex hormones, clinical features, and CSF biomarkers…The epigenetic association of Parkinson’s disease risk gene- GPNMB rs199347 with drinking
Objective: This paper examines the epigenetic association of rs199347 polymorphism variants of the GPNMB with drinking and DNA methylation changes. Background: Neuroinflammatory response induced by alcohol…Unsupervised physical capacity testing at home: a systematic review
Objective: Systematically review home-based physical capacity tests and their clinimetric properties in different patient populations with a chronic disease. Background: Physical capacity is a predictor…Does hyposmia induce apathy in early Parkinson’s disease? Lessons from structural brain connectivity
Objective: To study changes in microstructural integrity of white matter tracts associated with apathy in patients with early Parkinson’s disease (PD) and hyposmia Background: Smells…24(S)-Hydroxycholesterol and cognition in Huntington’s disease: results from two large patient cohorts (TRACK-HD and ENROLL-HD)
Objective: To investigate correlations between plasma levels of 24(S)-Hydroxycholesterol (24[S]-HC) and cognitive performance in participants with Huntington’s disease (HD) using data from ENROLL-HD. Background: HD…Impairment of SHH signaling in PD LRRK2 I1371V iPSC derived floor plate cells contribute to ontogenic origin of lower dopaminergic-neuron yield
Objective: To estimate SHH responsiveness & signaling of Floor Plate Cells (FPCs) derived from LRRK2 I1371V PD patient-iPSCs along with its link with LRRK2 I1371V…
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