Novel utilization of deep brain stimulation in the pedunculopontine nucleus for treatment of childhood-onset dystonia
Objective: Investigate the efficacy of deep brain stimulation (DBS) in the pedunculopontine nucleus (PPN) for the treatment of dystonia in pediatric patients. Background: Deep brain…The phenotypic spectrum and assessment of severity in patients of Spinocerebellar Ataxia-12.
Objective: To describe clinical phenotype, manifestations, and assess tremor severity using standard rating scale in genetically confirmed patients with SCA12. Background: Spinocerebellar Ataxia-12 (SCA12) occurs…Development and Validation of an Algorithm to Automatically Assess Motor Symptoms of Parkinson’s Disease
Objective: To assist non-specialists in evaluating patients with advanced Parkinson's disease who have difficulty visiting specialists’ hospitals, we developed an algorithm to automatically rate the…Experience of the LARGE-PD protocol in a health center in Buenos Aires, Argentina
Objective: Disseminate and inform the activity of the Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD) in Argentina. Background: The LARGE-PD consortium…Determination of metabotropic glutamate 2 receptor distribution with [3H]-LY-341,495 in hemi-parkinsonian rats with L-DOPA-induced dyskinesia
Objective: To determine the distribution and density of metabotropic glutamate 2 (mGlu2) receptors in the motor loop of the basal ganglia in 6-hydroxydopamine (6-OHDA)-lesioned rats…Myocardial sympathetic denervation biomarkers for early detection of prodromal DLB
Objective: Because of the time course of detecting DLB symptoms and signs, DLB is poorly diagnosed and hardly differentiate from AD, especially in early stage…Huntington’s disease in Senegal Epidemiological and clinical aspects
Objective: The objective of this study was to describe the epidemiological and clinical aspects of Huntington's disease in Senegal. Background: Huntington′s disease (HD) is an…Identification of reproducible metabolites for Parkinson’s Disease diagnosis using clinical data and computational modelling
Objective: To identify replicated metabolic markers of Parkinson’s Disease (PD) diagnosis from metabolomic studies and predict additional metabolic markers using computational metabolic modelling. Background: Reported metabolic markers of…The effect of anti- Parkinson’s disease granules and probiotics on gastrointestinal motility in the mouse model of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine -induced Parkinson’s disease
Objective: To investigate the effect of anti- Parkinson’s disease (anti-PD granules) and probiotics on gastrointestinal motility in the mouse model of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine( MPTP )-induced PD. Background:…Trajectories of Tardive Dyskinesia Impact Scale (TDIS) and Abnormal Involuntary Movement Scale (AIMS) over time with valbenazine treatment
Objective: To assess TDIS and global AIMS measures change trajectories using data from KINECT-4, an open-label 52-week trial assessing valbenazine in TD [1] Background: AIMS…
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