Efficacy of levodopa/carbidopa/entacapone replacement of levodopa/dopa decarboxylase inhibitors in treatment of Chinese Parkinson’s disease patients with wearing-off: a multicenter, randomized controlled, open label study
Objective: This study aimed to investigate the efficacy and safety comparison between LCE and Pramexol in Chinese PD patients with the wearing-off phenomenon. Background: Wearing…Analysis of the therapeutic potential of IkT-148009 in Parkinson’s disease
Objective: To evaluate the therapeutic potential of the selective, brain penetrant c-Abl inhibitor IkT-148009 in mouse models of progressive PD and the safety and tolerability…Validating wearable sensors as an assessment tool for Parkinson’s Disease
Objective: The objective of our pilot study was to assess the feasibility of using a portable accelerometer system to accurately identify motor findings in patients…Cognitive function in Parkinson’s disease: associations with perivascular space in basal ganglia
Objective: This study investigated the association of enlarged perivascular space (EPVS) and white matter hyperintensity (WMH) with cognitive impairment in Parkinson's disease (PD). Background: Cognitive…Long-term effects of a mobile technology-based brisk walking program on Parkinsonian symptoms in Parkinson’s disease – a randomized controlled trial
Objective: To evaluate the effectiveness of a 6-month mobile technology-based brisk walking program on motor and non-motor symptoms and self-perceived ability in people with Parkinson’s…Inferring Rigidity Scores in MDS-UPDRS Motor Assessment from Other Items
Objective: This study aimed to explore the possibility of inferring rigidity scores in MDS-UPDRS assessments from other items to enhance the accuracy of clinical evaluations…Impact of endpoint selection on sample size calculations for disease-modifying clinical trials in Parkinson’s disease patients with GBA1 mutations
Objective: To assess clinical trial sample size estimations under variable simulated scenarios for Parkinson’s disease (PD) patients with mutations in the β-glucocerebrosidade gene (GBA1). Background:…Parkinson’s disease and human gut microbiota in an Egyptian population: a pilot study
Objective: The main objective of our research is to decipher the association between the gut microbiota and Parkinson's disease in an Egyptian cohort. Background: Parkinson’s…PD.ai – Detection of Parkinson’s Disease with gait-based biomarkers using AI techniques
Objective: This study evaluated the utility of Artificial Intelligence (AI) in detection of patients with Parkinson’s disease from stride dynamics. Background: Parkinson’s Disease (PD) is…Effects of cerebellar cTBS on motor symptoms in Huntington’s disease: a feasibility and pilot study
Objective: To evaluate the feasibility and preliminary clinical effects of a single session of cerebellar cTBS in patients with Huntington's disease (HD) with mild-moderate motor…
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