Quasi tandem repeat in TCERG1 may influence age at onset of X-linked dystonia-parkinsonism
Objective: To investigate whether the hexamer repeat in the TCERG1 gene plays a role in modifying disease onset in X-linked dystonia-parkinsonism (XDP). Background: Recently, it…Education and the motor effects of dopamine loss in Parkinson’s disease
Objective: To examine the relation between education and dopamine signal loss in PD. Background: In support of the cognitive reserve concept, it has consistently been…New machine learning approaches in tic detection: Seeking to learn more about the characteristic of tics
Objective: To develop a machine learning tool to distinguish between facial/head tics in people with Tourette syndrome and spontaneous movements in healthy controls. Background: Distinguishing…Minimum clinically important difference (MCID) on the Unified Wilson Disease Rating Scale (UWDRS) Part III: results from the Phase 3 FoCus Trial
Objective: Minimum clinically important differences (MCID) on the Unified Wilson Disease Rating Scale (UWDRS) Part III were estimated using data from a phase III trial…In vivo proteomic investigation of deeply phenotyped parkinsonian syndromes for biomarkers of differential diagnosis
Objective: To investigate deeply-phenotyped cohorts of parkinsonian syndromes using proteomic technologies for identification of biomarkers for differential diagnosis Background: Proteomic technologies like Olink® Explore 3072…Evaluation of cases of psychosis from opicapone safety data
Objective: Investigate the likelihood of association of Opicapone (OPC) with psychotic symptoms (other than hallucinations). Background: Neuropsychiatric symptoms frequently occur in Parkinson’s Disease (PD) patients,…To stimulate or not to stimulate? Bilateral subthalamic (STN) Deep Brain Stimulation (DBS) in cases of young-onset parkinsonism with mitochondrial dysfunction induced neurodegeneration.
Objective: To describe two cases of young-onset parkinsonism (YOP; case 1 with mitochondrial membrane protein associated neurodegeneration (MPAN) due to a heterozygous mutation in C19orf12;…Continuous subcutaneous levodopa/carbidopa infusion with ND0612 for patients with Parkinson’s disease and motor fluctuations: Results from the Phase 3 randomized, active-controlled BouNDless study
Objective: Determine the efficacy, safety, and tolerability of ND0612 versus oral immediate-release levodopa/carbidopa (IR-LD/CD) in people with Parkinson’s disease (PwP) experiencing motor fluctuations. Background: ND0612…Post encephalitic dystonia-ataxia syndrome
Objective: To describe a young man with post encephalitc dystonia-ataxia with transient worsening following a febrile episode Background: We had a 19 year old young…The effects of mental imagery on balance, anxiety and quality of life of older people with early stage of dementia: Preliminary data
Objective: To examine the effectiveness of MI on balance; anxiety and quality of life of older adults with early stage of dementia. Background: Dementia is…
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