Effect of ADX-88178, a highly-selective mGlu4 PAM, on parkinsonism, dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset
Objective: To investigate the effect of the metabotropic glutamate 4 (mGlu4) positive allosteric modulator (PAM) ADX-88178 on parkinsonism, dyskinesia and psychosis-like behaviours (PLBs) in the…Metoclopramide-induced acute dystonic reaction caused by CYP2D6 *4/*4 and CYP2D6 *10/*10 genotypes
Objective: Objective is to demonstrated the role of CYP P450 2D6 polymorphisms in metoclopramide-induced acute dystonic reactions. Background: Metoclopramide can induce acute extrapyramidal reactions by…blepharoplasty yes or not? a single-centre study on the influence of blepharoplasty on the treatment with botulinum toxin injections.
Objective: To compare the responses to the BoNT injections of patients who underwent or not to blepharoplasty (Blepharoplasty YES/NO), in order to clarify if the…Pain in Monogenic Parkinson’s disease: A systematic review
Objective: We investigated the hypothesis that genotypes may influence pain phenotype in Parkinson's disease (PD) patients. The presence of pain, its subtypes, severity, and time in relationship…Rest Tremor in Parkinson’s Disease Is Associated with Increased Ipsilateral DAT Binding
Objective: To investigate the connection between striatal dopamine transporter binding and cardinal motor symptoms of Parkinson’s disease. Background: The three cardinal motor symptoms of Parkinson’s…The role of RNA-carrying exosomes in synaptic physiology and in synucleinopathies
Objective: Our goals were: (i) to characterize the molecular mechanisms associated with the transfer of miRNAs from astrocytes to neuronal synapses via exosomes in transgenic…Frequency of Parkinson’s Disease in All Case Hospitalization Among Native Hawaiian/Pacific Islanders, Asian American Subgroups and Whites
Objective: To determine if the proportion of hospitalized patients with Parkinson’s Disease (PD) in Hawaii differs among Native Hawaiians/Pacific Islanders (NHPI), American Asians (AA), and…Accelerometric Classification of Resting and Postural Tremor in Essential Tremor and Parkinson’s Disease
Objective: To investigate the predictive value of different accelerometry metrics for clinical ratings of Essential Tremor (ET) and tremor in Parkinson’s Disease (PD). Background: To…Cerebellar ataxia in Hypomyelinating Leukodystrophies: A case series
Objective: We present a case series of cerebellar ataxia due to hypomyelinating leukodystrophies (HLDs). Background: HLDs are a group of disorders arising from primary deficit…Characterisation of the pharmacokinetic profile of L-DOPA in the common marmoset
Objective: To determine the pharmacokinetic (PK) profile of L-3,4-dihydroxyphenylalanine (L-DOPA) in the common marmoset (Callithrix jacchus). Background: The common marmoset has been used to model…
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