Parkin Coregulates Glutathione Metabolism in Adult Brain to Contribute to Redox Homeostasis
Objective: We sought to determine whether the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis in vivo. Background: The mechanisms by which…Freezing of gait in Parkinson’s disease with glucocerebrosidase mutations: prevalence, clinical correlates and effect on quality of life
Objective: Mutations in glucocerebrosidase (GBA) can change the phenotype of Parkinson’s disease (PD). This study aimed to explore the clinical characteristics of freezing of gait…The role of the glymphatic system on the severity and distribution of alpha-synuclein pathology in alpha-synuclein fibril induced rat model of Parkinson’s disease
Objective: The aim of this study is to investigate the contribution of the glymphatic system to the pathophysiology of Parkinson's disease (PD). Background: Neurotoxicity of…Connectomic DBS informed multifocal transcranial direct current stimulation (tDCS) in Parkinson’s Disease: a crossover double blinded study
Objective: To determine if non-invasive neuromodulation of a network previously identified through invasive neuromodulation could improve motor symptoms in Parkinson's disease (PD). Background: A recent…Cortical mean diffusivity changes in Parkinson’s disease with probable RBD
Objective: To investigate cortical mean diffusivity (cMD) as a sensitive measure to identify subtle microstructural cortical changes in Parkinson’s disease (PD) patients with probable REM…Electronic Development of the MDS-UPDRS and MDS-NMS: Process and User Feedback
Objective: To describe the processes for development and obtaining user feedback of the electronic versions of the MDS Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) and…Physical exercise as a promising option for treating fatigue in Parkinson’s disease? Results of a systematic review and meta-analysis of non-pharmacological interventions
Objective: To give an update on randomized controlled trials (RCT) including non-pharmacological intervention approaches that examine effects on fatigue in people with Parkinson’s disease (PD).…Subject-specific investigation of pathways underlying therapeutic outcomes of deep brain stimulation for Essential Tremor
Objective: To relate subject-specific pathway activation models of motor thalamic deep brain stimulation (DBS) to clinical outcomes in patients with Essential Tremor (ET). Background: Computational…The Dystonic Drive – A Systematic Review on Coherence Analysis in Dystonia
Objective: To perform a systematic review on coherence analysis in dystonia. We focus on different modalities and describe the relation of abnormal coherent frequency bands…Remote monitoring of physical activity in Progressive Supranuclear Palsy (PSP) using wearable sensors
Objective: To remotely monitor physical activity in people with PSP and to correlate it with disease progression on the modified PSP Rating Scale (mPSPRS-21). Background:…
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