Sleep Characteristics in Idiopathic and Genetic Parkinson’s Disease
Objective: To investigate sleep features among individuals with genetic subgroups of PD, including LRRK2 G2019S-PD, GBA-PD, and iPD (idiopathic PD with no known genetic variant). Background:…Expanding Diversity of Parkinson’s Disease and Related Disorders Genetic Data: from the Global Parkinson’s Genetics Program
Objective: To expand the research dataset for Parkinson’s Disease (PD) and related disorders by including >50,000 participants globally who have been genotyped or whole genome…7year followup of Asia’s first case of sporadic ATP6AP2 Mutation: α-synucleinopathy or tauopathy?
Objective: ATP6AP2 mutation, previously described in literature to cause early onset Parkinson’s disease (PD) with atypical signs, evolved into frontotemporal lobar degeneration in a 7year…The Landscape of Neurodegeneration with Brain Iron Accumulation in Indian patients: Lessons from a Multicentric Cross-sectional Study
Objective: To delineate clinical, molecular, and radiological landscape of patients with Neurodegeneration with Brain Iron Accumulation (NBIA) in a nationwide Indian cohort. Background: NBIAs are…Unraveling the Complexity of Neurodegenerative Disorders: A Case Report of PKAN Suspected in a 24-Year-Old Patient with Severe Dystonia
Objective: To present a case study of a 24-year-old patient with severe dystonia and cognitive decline, suspected to have Pantothenate Kinase-Associated Neurodegeneration (PKAN), a rare subtype…The Protective Effect of Sutherlandia frutescens in a Rotenone-Induced Rat Model of Parkinson’s Disease.
Objective: The objective of this study was to investigate the impact of rotenone, a pesticide associated with Parkinson's-like symptoms, and Sutherlandia frutescens (SF), a plant…Altered EEG Theta Activity Characterizes Parkinson’s disease with Levodopa-induced Dyskinesia
Objective: We explored the relationship between the build-up and the downscaling process in patients with Parkinson’s disease by analyzing theta frequency spectral bands. Background: During…Clinical applications of cortical finely tuned gamma oscillations induced via subthalamic deep brain stimulation in Parkinson’s disease
Objective: To investigate the clinical relevance of entraining finely tuned gamma (FTG) oscillations via deep brain stimulation (DBS) in Parkinson’s disease (PD). Background: Prior studies…IPSC-derived Cortical Neurons from Parkinson’s Patients with VPS35 Mutation show Defects in Synapto- and Neurogenesis
Objective: Investigate whether the Parkinson’s disease (PD) VPS35 D620N mutation leads to synaptic dysfunction in human cortical iPSC-derived neurons. Background: Early presynaptic dysfunction and cortico-striatal…Sexual Dimorphism in Clinical Subtypes, Biomarkers and Disease Progression of Parkinson’s Disease
Objective: To investigate differences in clinical subtypes, biomarkers, and course of progression in Parkinson’s disease (PD) between the two biological sexes. Background: PD is a…
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