Study of the functional role of circulating extracellular vesicles as mediators of inflammation in cellular models of Parkinson`s disease
Objective: To study mechanisms of cellular inflammation and neurodegeneration of EVs derived from patients with PD at different disease stages in cell-based disease models. Background:…Progression of motor asymmetry in the MDS-UPDRS III in Parkinson’s Disease with and without REM Sleep Behavior Disorder over five years
Objective: To compare progression of motor asymmetry using the MDS-UPDRS-III in Parkinson’s Disease (PD) with and without probable REM Sleep Behavior disorder (pRBD) over 5…Concordance of Neuropathologic Diagnosis of Lewy Body Disease with Baseline Alpha-Synuclein Seed Amplification Assay in PPMI
Objective: To determine whether the alpha-synuclein seed amplification assay (aSyn-SAA) performed on cerebral spinal fluid (CSF) collected at the baseline (BL) PPMI visit is concordant…A case of progressive supranuclear palsy followed by dementia with Lewy bodies
Objective: We report a case of dementia with Lewy bodies (DLB) that was diagnosed one year after the diagnosis of PSP. Background: Progressive supranuclear palsy…Pallidotomy as a Therapeutic Option for Patients with Advanced Parkinson’s Disease: Case Study
Objective: The aim of this research is to assess unilateral pallidotomy as a surgical alternative for Parkinson's Disease (PD), emphasizing improvements in contralateral motor symptoms…Case Report: An Unusual Case of Corticobasal Syndrome
Objective: To describe a patient with corticobasal syndrome (CBS) and biomarker evidence of multiple proteinopathies. Background: CBS is a clinically heterogeneous syndrome caused by several…PSP-Like Syndrome Associated with Dysautonomic Findings as a Presentation of an Anti-Iglon5 Antibody-Related Encephalopathy
Objective: Report a case of a PSP-like syndrome associated with dysautonomic findings as a presentation of an anti-IgLON5 antibody-related encephalopathy. Background: Antibodies against immunoglobulin-like cell…CANVAS: think to assess cognition!
Objective: To determine the frequency and severity of cognitive impairment in RFC1-positive patients and comprehensively describe the pattern of cognitive disorders. Background: Cerebellar ataxia, neuropathy,…Spatial Memory and Processing Speed as Cornerstones in Predicting Falls in Parkinson’s Disease
Objective: To build a fall prediction model that includes cognitive and motor outcomes in a subset of patients with Parkinson's disease (PwPD) enrolled in the…Incident & Prevalent Dementia in Individuals with Parkinson’s Disease in the Framingham Heart Study
Objective: To examine incident and prevalent dementia cases in individuals with Parkinson's Disease (PD) within a longitudinal population-based study Background: Longitudinal studies have found that…
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