Detection of α-synuclein seeds in skin samples from PPMI participants
Objective: To evaluate the presence of α-synuclein seeds (syn-seeds) in skin samples from PPMI participants, including prodromal, early and late Parkinson’s disease (PD) using a…Long-Term Efficacy and Determinants of Motor and Quality-of-Life Outcomes Following Bilateral GPi-DBS in Dystonia
Objective: The present study aimed to evaluate the clinical features and clinical outcomes in dystonia patients who underwent bilateral deep brain stimulation of the globus…Quantitative susceptibility mapping with 7T MRI as a novel imaging biomarker for periventricular degeneration in normal pressure hydrocephalus: A pilot study
Objective: We try to investigate periventricular susceptibility alterations using QSM to establish a novel, accurate early imaging biomarker for NPH. Background: Normal pressure hydrocephalus (NPH)…Revisiting Prodromal Diagnostic Criteria in MSA: The Need for Early MRI-Based Diagnosis
Objective: This prospective cohort study investigated the role of neuroimaging for the early and accurate identification of multiple system atrophy (MSA) in patients with indeterminate…Data-driven Trajectories of Atrophy Explain Clinical Heterogeneity Across Lewy Body Diseases
Objective: To identify data-driven spatiotemporal trajectories of brain atrophy across the Lewy body disease spectrum and establish their relationship to clinical heterogeneity, core symptom profiles,…Phase 2 Trial for the Treatment of Early-stage Parkinson’s Disease with TJ0113, a Small Molecule Mitophagy Activator
Objective: To investigate the efficacy and safety of TJ0113 for patients with early-stage Parkinson's disease. Background: Mitochondrial dysfunction, particularly decreased mitophagy, may contribute to the pathogenesis of…Digital acoustic assessment of alleviating maneuvers in laryngeal dystonia: a 2-patient case series
Objective: To assess whether digital acoustic analysis can objectively capture posture-dependent symptom modulation in laryngeal dystonia. Background: Objective tools for quantifying alleviating maneuvers in laryngeal…Standardised Home-Based Walk Tests Can Capture Gait Differences in Parkinson’s Disease Using Wearable Sensors
Objective: To evaluate the feasibility and discriminative utility of a standardised home-based walk test using wearable sensors in people with Parkinson's disease (PwP). Background: Wearable…Handwriting in PRKN-PD: A Study of Movement Control
Objective: To explore differences in movement control between PRKN-PD and gene-negative YOPD patients using a structured handwriting task. Background: Idiopathic Parkinson’s disease (IPD) symptoms are…Development and initial feasibility of a Randomised Pilot Trial of Enhanced Tai Chi for Parkinson’s Disease
Objective: To describe the design and feasibility of a randomised controlled pilot study evaluating an Enhanced Tai Chi intervention for people with Parkinson’s disease (NCT07297368).…
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