Comparative efficacy and safety of Safinamide versus Opicapone in Japanese patients with Parkinson’s Disease and wearing-off: A matching-adjusted indirect comparison
Objective: To compare efficacy and safety outcomes with safinamide and opicapone as adjuncts to levodopa in Parkinson’s disease (PD) patients with wearing-off using an anchored…Levodopa-Responsive Dystonia in Adenylosuccinate Lyase (ADSL) Deficiency Treated With Bilateral GPi Deep Brain Stimulation
Objective: To describe levodopa-responsive dystonia in ADSL deficiency and the use of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) for refractory symptoms. Background:…Bridging the Genomic Gap: Ancestry-Aware Polygenic Risk and Variant Discovery in African Parkinson’s Disease Cohorts
Objective: This study evaluates the shift from Euro-centric data to a diversified landscape. We aim to quantify the performance of European-derived Polygenic Risk Scores (PRS)…myParkinson’s Wellbeing Programme for people newly diagnosed and their care-partners
Objective: Receiving a diagnosis of Parkinson’s can be challenging to one’s mental and emotional health and anxiety and low mood are common. For many people,…Dynamics of Motor Fluctuations and Medication Challenges in Parkinson’s Disease
Objective: To investigate the dynamics of tremor, bradykinesia, and finger dexterity during the OFF-to-ON transition using objective measures. Additionally, assesses medication administration challenges through a…Identification of a Novel MYORG Mutation in Autosomal Recessive Idiopathic Basal Ganglia Calcification-7 (IBGC7): A Case Report
Objective: To report a case of parkinsonism with brain calcification, novel variant Background: Idiopathic Basal Ganglia Calcification (IBGC) is a rare neurological condition. With abnormal,…Cognitive Profile In Indian Patients with Spinocerebellar Ataxia (SCA) – Prospective Cross-sectional Study
Objective: To evaluate the prevalence, spectrum, and severity of cognitive impairment in Indian patients with genetically confirmed SCA and corelate with motor severity. Background: Beyond…Single centre experience with subcutaneous foslevodopa/foscarbidopa for GBA Parkinson’s disease
Objective: To describe the clinical outcomes of two patients with GBA Parkinson’s disease (GBA-PD) and severe motor fluctuations treated with subcutaneous foslevodopa/foscarbidopa (fld/fcd) infusion. Background:…Clinical and Autonomic Correlates of Chronic Sialorrhea in Parkinson’s Disease: A Questionnaire-Based Study with Cluster Analysis of Autonomic and Dysphagia Burden
Objective: To examine factors associated with drooling in patients with Parkinson’s disease (PD), patient awareness and perceptions of botulinum toxin therapy, and the relative contributions…Mechanisms of PLA2G6 Deficiency Impacting Mitochondria-associated membranes in Parkinson’s Disease
Objective: This study aims to explore the functions of PLA2G6 protein at the endoplasmic reticulum-mitochondria interface, unveiling the potential mechanisms of PLA2G6-related Parkinson’s disease (PD)…
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