Assessing The Role Of Afg3l2 Pathogenic Variants In Parkinson’s Disease
Objective: The aim of this study is to investigate the potential link between AFG3L2 rare pathogenic/likely pathogenic variants with Parkinson’s disease (PD). Background: AFG3L2 is…Markerless Kinematic Analysis of Gait and Turning in Parkinson’s Disease
Objective: To investigate gait and turning biomechanics in individuals with Parkinson’s disease using a 3D markerless motion capture system following a dry needling intervention. Background:…PEST-PD: Preliminary Findings from an Ongoing Longitudinal Observational Study for Prodromal Parkinson’s disease in farmers exposed to pesticides.
Objective: To compare the risk for prodromal Parkinson's disease (PD) in subjects exposed and non-exposed to pesticides Background: Farmers may have an elevated risk of…GBA1 deficiency promotes tau and TDP-43 co-pathology
Objective: To determine whether mutations in the gene beta-glucocerebrosidase 1 (GBA1), the strongest genetic risk factor for PD, promote tau and TDP-43 co-pathology alongside Lewy…Utility of DaTscan in Children with suspected Juvenile Parkinsonism: A Single-Centre Cohort Study
Objective: To evaluate the utility of DaTscan imaging in a cohort of paediatric patients referred to a tertiary neurology centre (Great Ormond Street Hospital, GOSH).…Sublingual apomorphine for parkinsonian tremor: Post-hoc analysis of pivotal trial data
Objective: We explored tremor outcomes associated with apomorphine sublingual film (SL‑APO) in patients with a tremor‑dominant PD phenotype. Background: Tremor is a common and disabling…Ecological Momentary Assessment Monitoring Captures Motor Fluctuation Improvement after DBS in Parkinson’s Disease
Objective: To evaluate whether mobility measures based on ecological momentary assessment (EMAs) capture deep brain stimulation (DBS) motor improvement in Parkinson’s disease (PD) and correlate with clinician-rated motor impairment (UPDRS III) and motor…Quantitative Changes in Speech After Focused Ultrasound Thalamotomy in Parkinson’s Disease and Essential Tremor
Objective: To compare speech performance following unilateral MR-guided focused ultrasound (MRgFUS) targeting the ventral intermediate nucleus (VIM) of the thalamus in Parkinson’s disease (PD) and…Motor outcomes and safety of staged bilateral MR-guided focused ultrasound subthalamotomy in Parkinson disease
Objective: To assess the 12-month efficacy and safety of staged bilateral STN-MRgFUS in patients with PD. Background: MR-guided focused ultrasound subthalamotomy (STN-MRgFUS) has emerged as…Clinical study on acupuncture improving anxiety in Parkinson’s disease by regulating the HPA axis
Objective: To investigate the effect of acupuncture versus sham acupuncture for PDA. Background: Anxiety in PD (PDA) is identified by continuous feeling of worry, muscle tension,…
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