Beyond the “best contact”: correlation of ai-guided dbs contact distribution and subthalamic nucleus beta physiology in parkinson’s disease patients
Objective: We hypothesized that optimal stimulation setting may involve a muti-contact configuration rather than a single contact with the largest therapeutic window (TW). We aimed…Safindream Safinamide as First Add On to Levodopa Improves Nonmotor Symptoms in Parkinson disease A Prospective Real World Study
Objective: To evaluate the real-world effectiveness of safinamide on non-motor symptoms, sleep disturbances, and mood in patients with Parkinson's disease receiving safinamide as the first…Dopamine depletion does not mitigate striatal reward prediction error signals
Objective: To elucidate the role of dopamine in computing reward prediction error signals in the basal ganglia Background: Phasic discharges of midbrain dopamine neurons are…SLC20A2 Splice-Site Mutation (c.935-1G>A) Presenting as levodopa-responsive parkinsonism: Expanding the Phenotypic Spectrum of Primary Familial Brain Calcification
Objective: To report a case carrying a rare splice-site mutation in the SLC20A2 gene presenting as early-onset, levodopa-responsive parkinsonism. Background: Primary Familial Brain Calcification (PFBC)…Neurofilament Light Chain as a Prognostic Marker of Motor Progression in Parkinson’s Disease: A Systematic Review
Objective: To identify systematically studies evaluating CSF, serum, and plasma NfL as a prognostic factor for clinical progression in PD and to describe study characteristics…The Prevalence of Parkinson’s Disease in Kilifi County, Kenya: A ‘Transforming Parkinson’s Care in Africa’ (TraPCAf) study
Objective: We aimed to determine the prevalence of PD in Kilifi County, Kenya within the Kilifi Health and Demographic Surveillance System and evaluate the performance…Dual-Task Gait Costs do not Increase Across Stages of Parkinson’s Disease
Objective: To investigate whether motor and cognitive dual-task (DT) gait costs differ between early and intermediate stages of Parkinson’s disease (PD). Background: In PD, reduced…Hybrid deep brain stimulation conversion using the S8 adaptor in Parkinson’s disease
Objective: To evaluate the feasibility and short-term outcomes of hybrid deep brain stimulation (DBS) conversion using the S8 adaptor in Parkinson’s disease (PD). Background: DBS…A Comparison of Video-Based and Sensor-Based Movement Measurements in Cervical Dystonia
Objective: We compared markerless video-based motion analysis with inertial measurement unit (IMU)-based kinematic recordings in healthy controls and patients with CD. Background: Cervical dystonia (CD)…Beyond Relaxation: Can Self-Initiated Therapeutic Tremors Improve Functional Gait and ADL in Parkinson’s Disease?
Objective: The primary aim of this study was to investigate the effects of exercise with and without self-initiated unclassified therapeutic tremors (SUTT) on dynamic balance…
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