RESET-DBS: An exploratory study on the safety and efficacy of personalized burst-patterned deep brain stimulation (DBS) in Parkinson’s Disease (PD)
Objective: To assess the safety and efficacy of a personalized burst patterned STN-DBS (bDBS) vs. conventional high-frequency DBS (cDBS). Background: A physiological rationale suggests possible…Patient self-rated Improvements with Opicapone: From randomized trials to Phase IV studies in fluctuating Parkinson’s Disease
Objective: To perform a descriptive comparison of patient-reported perception of improvement with opicapone across phase III and IV studies in patients with fluctuating Parkinson’s disease…Real-World Relationship Between Beta-Band LFP Activity and Motor States in Parkinson’s Disease
Objective: To evaluate the relationship between 10-minute averaged beta-band local field potential (LFP) activity recorded from implanted deep brain stimulation (DBS) systems and motor state…Non-Motor Symptoms in Hemifacial Spasm: A Cross-Sectional Study from a Brazilian Public Tertiary Center
Objective: To determine clinical characteristics of non-motor symptoms in patients with primary hemifacial spasm (HFS) at a tertiary public center in Brazil. Background: HFS is…Association of Neurofilament Light Chain with Substantia Nigra Degeneration in Parkinson’s Disease
Objective: This study aims to investigate the association between serum neurofilament light chain (NfL), microstructural changes in the substantia nigra, and clinical manifestations in Parkinson’s…Adult-Onset Alexander Disease with Paroxysmal Myoclonus-Like Episodes and a Novel GFAP Variant
Objective: To report an atypical case of suspected adult-onset Alexander disease presenting with unusual myoclonus-like episodes and progressive spastic gait, associated with a novel GFAP…Data-driven operational definition of square-wave jerks to optimize diagnostic discrimination of progressive supranuclear palsy
Objective: To use a data-driven approach to create an optimal SWJ definition and to assess its diagnostic utility in PSP. Background: The Movement Disorder Society…Smartwach Actigraphy for Detection of REM Sleep Behavior Disorder: The dBM-DEV Study
Objective: To evaluate feasibility and performance of multi-night at-home recordings using a smartwatch to (1) detect REM sleep behavior disorder (RBD) compared with polysomnography (PSG)…Patient perspectives on meaningful symptoms and disease progression in Parkinson’s Disease (PD): Interim findings from the Patient Endpoint Preference Project (PEPP)
Objective: The Patient Endpoint Preference Project (PEPP) aims to identify and quantify early‑stage PD patients’ priorities around symptoms and their progression using patient‑reported questionnaires. The…Using Musical Groove to help People move in Parkinson’s: A Participatory Action Research Study of Music and Movement.
Objective: To co-design a questionnaire with people with Parkinson’s disease (PwP) examining how musical groove relates to movement, motivation, and wellbeing in daily life, and…
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