Anticipatory Language Prediction ERPs Detect Early Neurophysiological Changes in Asymptomatic Huntington’s Disease
Objective: To determine whether ERP markers of anticipatory semantic prediction and post-target integration detect early functional brain changes in asymptomatic Huntingtin gene-expansion carriers (HGEC) compared…Proteome-Wide Association and Mendelian Randomization Analyses Identify Plasma GUSB as a Potential Biomarker for Multiple System Atrophy
Objective: To identify plasma protein biomarkers associated with MSA and investigate their potential causal relationships using integrative proteomic and genetic approaches. Background: Multiple System Atrophy…Quanti-tau-PET Study of PI‑2620 Tau-PET Quantification in Progressive Supranuclear Palsy
Objective: *Establish a quantitative analysis framework for PI‑2620 tau-PET in progressive supranuclear palsy (PSP);*Compare tau-PET uptake in PSP versus control subjects;*Assess correlations with clinical variables…Hemoglobin Levels and Non Motor Symptoms in Parkinsons Disease Patients with Modified Hoehn and Yahr Scores
Objective: This study aims to explore the association between hemoglobin (Hb) levels and the severity of non motor symptoms in Parkinson’s disease as evaluated through…Painful legs moving toes spectrum disorders – a systematic review
Objective: To investigate the clinical characteristics of painful legs moving toes (PLMT) spectrum disorders. Background: Classic PLMT is a rare movement disorder characterized by continuous involuntary…Disparities in Accessing MRI-Guided Focused Ultrasound (MRgFUS) and Gamma Knife for Tremor Treatment: A Retrospective Chart Review
Objective: Quantitatively describe demographic disparities among patients with tremor treated with MRgFUS and GK. Background: Thalamotomy is an established and effective treatment of tremor when…Insight into α-synuclein pathogenicity by a human cell model with suppressed NatB-mediated N-terminal acetylation
Objective: Our aim was to study α-syn Nt-acetylation and its impact on the disease-relevant properties of this protein in cell models to shed light on…Anhedonia in Parkinson’s Disease: Prevalence and Clinical Correlations
Objective: To investigate the prevalence of anhedonia in patients with Parkinson’s disease (PD) and to analyze its relationship with age, motor deficit severity, depression, and…Clinical Underestimation of Wearing-Off in Parkinson’s Disease: Patient-Reported Outcomes Versus Clinical Assessment and Impact on Quality of Life
Objective: To prospectively investigate the frequency and determinants of wearing-off (WO) in Parkinson's disease (PD) using a validated patient-reported instrument compared to routine neurological evaluation,…Can digital Mobility Outcomes differentiate cognitive impairment in Parkinson’s Disease?
Objective: To determine if digital mobility outcomes (DMOs) differentiate between those with and without cognitive impairment in Parkinson’s disease (PD). Background: Cognitive impairment is common…
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