The Effectiveness of Rivastigmine in Parkinson’s Disease: Impact on Motor Symptoms, Gait, Cognitive Function, and Falls – A Systematic Review and Meta-Analysis of Double-Blind, Placebo-Controlled RCTs
Objective: To evaluate the efficacy of rivastigmine in patients with Parkinson’s disease (PD) by assessing its impact on motor symptoms, cognitive function, gait, falls, and…Decreased cholinergic activity in specific brain regions associated with slower lower limb visual choice reaction time in Parkinson’s disease: A [18F]-FEOBV PET study
Objective: To investigate the relationship between cholinergic system changes, as measured by vesicular acetylcholine transporters (VAChT) [18F] fluoroethoxybenzovesamicol ([18F] FEOBV) binding in PET, and cognitive performance, measured as…Impaired Speech Perception in Noise (SPiN), Hearing Loss, and Cholinergic Denervation in Parkinson’s Disease
Objective: This study will investigate the relationships among speech-perception-in-noise (SPiN), hearing acuity, and cholinergic system changes in patients with PD. Background: Recent studies highlight a…The Role of α7 Nicotinic Acetylcholine Receptor in Mitochondrial Homeostasis and Neuroprotection
Objective: This study aims to explore the neuroprotective role of α7 nicotinic acetylcholine receptor (α7nAChR) in mitochondrial homeostasis and its potential as a therapeutic target…Striatal dopamine- and basal forebrain cholinergic-dependent brain metabolism and cognition in Parkinson’s disease
Objective: To explore the interrelation of striatal dopamine, cholinergic basal forebrain volume, brain metabolism, and cognition in PD. Background: Parkinson’s disease (PD) involves multiple neurotransmitter…Cholinergic activity associates with cognitive function in PD using [18F]VAT
Objective: To map the relationship between cholinergic activity in Parkinson Disease (PD) and cognitive performance and identify any differences in this relationship in cognitive impairment.…Asymptomatic GBA1 Mutation Carriers Have Increased Cortical Cholinergic Activity
Objective: The objective of this study was to assess cholinergic activity changes in patients with Parkinson’s disease carrying GBA1 variants(GBA-PD) and in non-manifesting carriers(GBA-NMC) using…Brain Cholinergic Changes in Progressive supranuclear palsy: A single-subject voxel-wise approach to understanding heterogeneity
Objective: To characterize individual-level topographical patterns of cholinergic changes compared to controls in Progressive Supranuclear Palsy (PSP) using a voxel-wise approach. Background: The cholinergic system…Cholinergic denervation is more severe in patients with Parkinson disease compared to Progressive Supranuclear Palsy-Parkinsonism subtype: A [18F]-FEOBV PET study
Objective: : To investigate cholinergic brain regional differences between Progressive supranuclear palsy with parkinsonism (PSP-P) and Parkinson's disease (PD), using the highly selective radiotracer for…Increased cholinergic activity in specific brain regions associated with the presence of dyskinesias in Parkinson’s disease: A [18F]-FEOBV PET study
Objective: To explore the role of cholinergic dysfunction in dyskinesia symptoms in people with Parkinson’s disease (PD). Background: Dyskinesias, involuntary and sometimes excessive or uncontrolled…
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