A Phase 2 Study of ATH434 a Novel Inhibitor of α-Synuclein Aggregation for the Treatment of Multiple System Atrophy
Objective: Describe baseline fluid and neuroimaging biomarker data of an early MSA study population Background: MSA is a rapidly progressive neurodegenerative disorder characterized by aggregated…MDS Clinical Supportive Criteria for Parkinson’s Disease are Associated with α-Synuclein Seed Amplification Assay Status
Objective: To assess the association between α-synuclein seed amplification assay (α-synuclein SAA) status with the supportive criteria of the MDS Clinical Diagnostic Criteria for Parkinson’s…Autoradiography characterization of novel alpha-synuclein radioligands [3H]Tg1-90B, [3H]M503-1619 and [3H]HY-2-15 in human post mortem brain
Objective: To characterize the in vitro binding properties of 3 radioligands for imaging α-syn aggregates in post mortem brain samples of synucleinopathies: [3H]TG-190B (Site 2),…Melatonin Modulates NLRP3 Inflammasome Activation through TLR2 to Protect Against Parkinson’s Disease
Objective: This study aims to investigate the impact of MLT on inflammation signaling pathway mediated by TLR2 in α-synuclein (α-syn) overexpressed BV2 cells and PD…Investigating Copy Number Variations in SNCA and PRKN in a Cohort of Kazakhstani Patients with Parkinson’s Disease and Healthy Controls
Objective: To investigate the frequency of copy number variations (CNVs) in SNCA and PRKN in a cohort of Parkinson’s disease (PD) patients and healthy controls…The effect of anti- Parkinson’s disease granules and probiotics on gastrointestinal motility in the mouse model of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine -induced Parkinson’s disease
Objective: To investigate the effect of anti- Parkinson’s disease (anti-PD granules) and probiotics on gastrointestinal motility in the mouse model of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine( MPTP )-induced PD. Background:…Selegiline drives autophagic secretion of α-synuclein
Objective: Our aim is to elucidate how selegiline drives extracellular secretion of α-synuclein (αS) and whether selegiline-induced αS secretion affects cell-to-cell transmission of αS. Background:…In vitro α–synuclein aggregation and propagation model
Objective: Developing an in vitro α–synuclein (α-s) aggregation and propagation model of human cortical networks for functionality studies. Background: Studying α–s pathology and its effects…The contribution of Brain Bank for Aging Research to pathomechanism of Parkinson’s disease
Objective: Objective: The aim of this paper is to present the result of the whole body screening of Lewy body pathology by Brain Bank for…The role of RNA-carrying exosomes in synaptic physiology and in synucleinopathies
Objective: Our goals were: (i) to characterize the molecular mechanisms associated with the transfer of miRNAs from astrocytes to neuronal synapses via exosomes in transgenic…
- « Previous Page
- 1
- …
- 15
- 16
- 17
- 18
- 19
- …
- 60
- Next Page »