Characterizing the genetic architecture of Parkinson’s disease in Latinos
Objective: By performing the first genome-wide association study (GWAS) of Parkinson’s disease (PD) in Latinos, we seek to interrogate the genetic architecture of PD in…Detection of alpha-synuclein aggregation from submandibular and esophageal tissue of patients with synucleinopathies
Objective: Utilize cyclic amplification methods to facilitate detection of aggregation prone forms of a-syn from submandibular or esophageal tissue of patients with syncleinopathies. Background: In…Alpha synuclein BAC transgenic mice as a preclinical model for disease-modifying therapies in Parkinson’s disease
Objective: The aim of this study is to make preclinical mice models for disease-modifying therapies in Parkinson's disease. Background: The prodromal stage of Parkinson's disease…Microbiome from Parkinson’s patients shows an increase in polyamines metabolism and differentially expresses microbial bacterial taxa compared to aged-matched normal controls
Objective: The goal of this study was to determine whether the microbiome from Parkinson’s disease (PD) has alterations in a) Polyamine metabolism and b) Expressed…Parkinson’s disease polygenic risk prediction and haplotype analysis in a South American cohort
Objective: We aim to evaluate the performance of a Parkinson’s disease (PD) polygenic risk score (PRS), estimated using genome-wide association (GWAS) data from a European…Cancerous inhibitor of protein phosphatase 2A in Parkinson’s disease
Objective: To investigate the expression level of Cancerous Inhibitor of Protein phosphatase 2A (CIP2A) in Parkinson’s disease (PD), and explore the relationship between CIP2A and…The exosomal a-syn filaments can be a novel biomarker of Parkinson’s disease
Objective: This study is aimed to investigate whether the number of exosomes, the amount of total or exosomal a-synuclein (a-syn) filaments in serum can serve as…Lack of sensitivity of full-depth upper gastrointestinal specimens as a prodromal biomarker for synucleinopathy in idiopathic REM sleep behavior disorder
Objective: To examine the phosphorylated alpha-synuclein (pAS) immunohistochemistry of the upper gastrointestinal (GI) tract tissue as a “prodromal” pathologic biomarker for synucleinopathy in idiopathic rapid…Evaluation of neuroprotection by human ENGRAILED-1 in a chronic AAV-hα-synuclein-A53T (AAV-A53T) rat model of Parkinson Disease
Objective: Investigate the long-term neuroprotective effect of a single bilateral injection of human ENGRAILED1 (hEN1) in a rat α-synuclein model of Parkinson Disease (PD). Background:…Neuritic pathology in Parkinson’s Disease results from loss of anti-oxidant response activity
Objective: To determine the link between α-syn accumulation and neuritic pathology in Parkinson’s Disease (PD). Background: Neurological dysfunction in PD is highly associated with pathological…
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