Alpha-synuclein promoter (SNCA-Rep1) polymorphism is associated with non-motor symptoms in early Parkinson’s disease
Objective: We sought to investigate the relationship between SNCA Rep1 allele length and NMS in PD. Background: Associations between the alpha-synuclein gene (SNCA) promoter region…Metabolomic Analysis of Fecal Matter from Parkinsonian Mice
Objective: Assess the metabolic changes in fecal matter in mice treated with an immunomodulatory therapy. Background: The cause of neuronal death in Parkinson’s disease (PD)…Deciphering the role of posttranslational modifications on α-synuclein aggregation and toxicity
Objective: The precise contribution of alpha-synuclein (ASYN) to neuronal dysfunction and death is still unclear. There is intense debate on the nature of the toxic…Functional Capacity in patients with Parkinson’s Disease are related to advanced glycation end-products
Objective: This study aimed to estimate the AGE consumption and formation in individuals with Parkinson's disease and to relate them with their functional capacity. Background:…The evaluation of exosomes as a biomarker of Parkinson’s disease
Objective: This study is aimed to investigate whether the number and the contents of serum exosomes can serve as a useful biomarker for the diagnosis…Identification of genetic alterations and SNCA mutation in Parkinson’s disease patients of Coimbatore Population, India
Objective: The aim of the study is to analyze the genetic alterations in SNCA gene and dopamine transporter in 22 PD patients of Coimbatore population.…Enhancing the Proteasomal Degradation of Alpha Synuclein: “The Hallmark” to attenuating the Progression of Parkinson’s Disease
Objective: The research aimed at preventing the accumulation of Alpha Synuclein in order to prevent it's accumulation. It is imperative that we also establish that…DCM extract of Scutellaria Pinnatifida modulate alpha-synuclein fibrillation and protects dopaminergic SH-SY5Y cells against rotenone
Objective: The aim of this study is to evaluate the effect of Dichloromethane extract (DCMex) of Scutellaria Pinnatifida (S) on of alpha-synuclein (ASN) and effect…Tissue Engineered Nigrostriatal Pathway as an Anatomically-Inspired Test-Bed for Evaluating Axonal Pathophysiology
Objective: We previously developed the first micro-tissue engineered nigrostriatal pathway encased in a tubular hydrogel with 3D structure, multicellular composition, and architecture of long axonal…A Phase 2 Study of the Efficacy, Durability and Safety of Ampreloxetine (TD-9855), a Norepinephrine Reuptake Inhibitor, Given Once-daily to Treat Neurogenic Orthostatic Hypotension (nOH) in Subjects with Synucleinopathies
Objective: To assess the efficacy and durability using validated symptom questionnaire OHQ, and safety of ampreloxetine, given once-daily to treat neurogenic orthostatic hypotension (nOH) in…
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