Systematic Assessment of 10 diagnostic marker candidates in biological fluids for Parkinson’s disease
Objective: To validate in serum and/or cerebrospinal fluid (CSF) diagnostic biomarker candidates identified from a systematic literature search including markers on axonal and synaptic integrity,…Amylin deposition in the brain of Parkinson’s disease patients
Objective: The objective of this study was to determine the presence of amylin deposits in the brain of subjects with synucleinopathies. Background: The link between…Ginsenoside Rb1 Prevents MPTP-Induced Changes in Hippocampal Memory via Regulation of the α-Synuclein/PSD-95 Pathway
Objective: To explore the effects of ginsenoside Rb1 on the cognitive impairment of Parkinson’s disease (PD) model. Background: Memory deficiency is a common non-motor symptom…GBA1 biomarkers in longitudinal CSF: GCase, Sphingolipids and alpha-synuclein
Objective: To assess the GBA1-pathway-specific biomarker profile in patient-derived CSF. Background: Heterozygous mutations in the GBA1 gene represent the most common genetic risk factor for…Investigation of the protective efficacy of alpha-synuclein-specific antibodies in a novel neuronal cell model for synucleinopathies
Objective: To investigate the protective efficacy of different alpha-synuclein (α-Syn)-targeting antibodies in a new model of α-Syn cell-to-cell spread. Background: The 14 kDa protein α-Syn…Parkinson’s disease-associated mutations of PLA2G6 alters the membrane dynamics and α-synuclein stability
Objective: To investigate the mechanism of α-synuclein (α-Syn) aggregation. Background: PLA2G6 has been isolated as the gene responsible for an autosomal recessive form of Parkinson’s…Cognitive ability characterization of rat model with mutated alpha-synuclein overexpression
Objective: The present study aims to assess cognitive function in a rat model of mutated alpha-synuclein overexpression in order to determine whether this model can…Dementia with Lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha-synuclein profile
Objective: Whether GBA1 mutations are associated with a CSF alpha-synuclein profile in DLB. Background: Patients with dementia with Lewy bodies (DLB) reveal a variable pathology…Wide distribution of alpha-synuclein oligomers in Creutzfeldt-Jakob disease detected by a novel proximity ligation assay
Objective: The objective of this work is to assess if oligomeric forms of alpha-synuclein exist in patients with Creutzfeldt-Jakob disease. Background: Prion diseases, the most…High repressive activity of olive extracts on the cell line model of Parkinson disease against ROS induction
Objective: Neurodegenerative diseases including Parkinson’s disease (PD) mostly accompany with induction of high ROS in neuronal cells. It is believed that unusual level of ROS…
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