Identification of genetic alterations and SNCA mutation in Parkinson’s disease patients of Coimbatore Population, India
Objective: The aim of the study is to analyze the genetic alterations in SNCA gene and dopamine transporter in 22 PD patients of Coimbatore population.…Enhancing the Proteasomal Degradation of Alpha Synuclein: “The Hallmark” to attenuating the Progression of Parkinson’s Disease
Objective: The research aimed at preventing the accumulation of Alpha Synuclein in order to prevent it's accumulation. It is imperative that we also establish that…DCM extract of Scutellaria Pinnatifida modulate alpha-synuclein fibrillation and protects dopaminergic SH-SY5Y cells against rotenone
Objective: The aim of this study is to evaluate the effect of Dichloromethane extract (DCMex) of Scutellaria Pinnatifida (S) on of alpha-synuclein (ASN) and effect…Tissue Engineered Nigrostriatal Pathway as an Anatomically-Inspired Test-Bed for Evaluating Axonal Pathophysiology
Objective: We previously developed the first micro-tissue engineered nigrostriatal pathway encased in a tubular hydrogel with 3D structure, multicellular composition, and architecture of long axonal…A Phase 2 Study of the Efficacy, Durability and Safety of Ampreloxetine (TD-9855), a Norepinephrine Reuptake Inhibitor, Given Once-daily to Treat Neurogenic Orthostatic Hypotension (nOH) in Subjects with Synucleinopathies
Objective: To assess the efficacy and durability using validated symptom questionnaire OHQ, and safety of ampreloxetine, given once-daily to treat neurogenic orthostatic hypotension (nOH) in…Longitudinal CSF-profile and brain pathology mirrors clinical course of LRRK2-Related Parkinson’s Disease
Objective: Do clinical cognitive profiles and CSF characterisitcs of Abeta1_42, total-tau, phospho-tau and alpha-synuclein during lifetime correspond to histopathological findings post-mortem in LRKK2-associated Parkinson’s disease…Baicalein incorporated nanoliposome disaggregates alpha-synuclein fibrils
Objective: The aim of this study is to evaluate the depolymerization effect of baicalein on mature fibrils of alpha-synuclein. Background: The aggregation and oligomerization of…A Lewy body disease of widely confirmed Lewy bodies in the cerebral cortexes including the occipital lobe without pathological changes in the hippocampal CA2/3 region
Objective: We present Lewy body disease (LBD) showing unique neuropathological findings which are widely recognized Lewy bodies (LBs) in the cerebral cortexes including the occipital…DNAJC13 in Parkinson’s disease; characterization of the p.N855S knock-in mouse model
Objective: To study the effects of DNAJC13 p.Asn855Ser mutant gene dysfunction in a physiological context, and to help define molecular mechanisms for disease, using a…A Phase 2 Dose Escalation Study of Ampreloxetine (TD-9855), a Norepinephrine Reuptake Inhibitor, Given Once-Daily to Treat Neurogenic Orthostatic Hypotension (nOH) in Subjects with Synucleinopathies
Objective: To assess the acute effects of ampreloxetine on the pressor response, improvement of symptoms and safety in a daily, single, escalating doses. Background: nOH…
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