Assessment of neurodegeneration and spreading of α-synuclein pathology induced by structurally defined α-synuclein assemblies in wild-type mice
Objective: The aim of this study was to investigate, in wild-type mice, the spreading and neurodegeneration induced by intracerebral injection of structurally well-defined α-synuclein assemblies…Physical and cognitive stimulation through environmental enrichment prevents early molecular pathology in a Parkinson´s disease model
Objective: Understand the molecular principles and identify genetic drivers underlying and mitigating the preventative effects of environmental enrichment on the unfolding of Parkinson´s disease (PD) pathology.…Fundamental limit of the alpha-synuclein immunohistochemistry using the endoscopic biopsy from the gastrointestinal tract as a biomarker for Parkinson disease: a case-control study
Objective: To investigate significance of the Lewy pathology in biopsy and surgical specimen in the gastrointestinal (GI) tract as an in-vivo biomarker for Parkinson disease (PD). Background: Alpha-synuclein…Serum lipid profile in Parkinsons disease patients from Southern Spain
Objective: Our first aim was to evaluate differences in the blood lipid profile levels between Parkinsons disease (PD) patients and healthy controls (HC). Secondly, in…Genetic, epigenetic and expression profiles in alpha-synucleinopathies
Objective: To determine whether each of the alpha-synucleinopathies has distinct methylation and/or expression profiles that distinguishes them from other disorders in this class. Background: The…Modeling Parkinson’s disease pathology by combined injection of fibrilar and monomeric α-synuclein in rat brain
Objective: Development of a fast and progressive Parkinson’s disease (PD) model in rat Background: α-Synuclein is a common link between sporadic and familial PD. Rodent…Antibody binding differences in alpha-synuclein from Parkinson’s disease and multiple system atrophy
Objective: Determine whether alpha-synuclein derived from Parkinson's disease (PD) and multiple system atrophy (MSA) brains has different conformations as defined by biochemical and antibody-based approaches. Background: There…Full sequencing and GWAS markers analysis of SNCA in RBD and progression to synucleinopathies.
Objective: To study the role of SNCA variants in REM sleep Behavior Disorder (RBD) and progression to synucleinopathies. Background: Individuals with properly diagnosed idiopathic RBD…Oligomeric alpha-synuclein and glucocerebrosidase activity levels in GBA-associated Parkinson’s disease
Objective: To evaluate alterations in the phosphorylated, oligomeric alpha-synuclein and GBA activity levels in plasma from patients with sporadic Parkinson's disease (sPD), PD patients with…Exploring aging-VMAT2 gene-rotenone interactions in a cell model for Parkinson’s disease
Objective: To develop a Parkinson's disease (PD) model based on aging, vesicular monoamine transporter 2 (VMAT2) gene susceptibility and chronic rotenone exposure in SK-N-SH cell,…
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