Association of impaired melatonin secretion with sleep disturbance in multiple system atrophy
Objective: To clarify whether there is impaired melatonin secretion and whether it is associated with sleep disturbance in patients with multiple system atrophy (MSA). Background:…Objective intestinal dysfunction in REM sleep behaviour disorder
Objective: To study objectively measured intestinal function, defined by intestinal volume, transit times, and colonic motility patterns in patients with idiopathic REM sleep behaviour disorder…Accelerometer-based measures and analyses of nonmotor symptoms of patients with Parkinson’s Disease
Objective: Through the monitoring of patients with PD during ON and OFF states, we aim at studying the detection of nonmotor symptoms (NMS) changes during…Gastrointestinal transit time in Parkinson’s disease -a novel 3D method
Objective: To study the GI transit time with a novel ambulatory electromagnetic system in PD patients and healthy controls. Background: The majority of Parkinson’s disease…The FDA is listening: Integrating the voice of the patient in drug development for Parkinson’s and Huntington’s diseases.
Objective: To present highlights from the Patient-Focused Drug Development (PFDD) meetings held at FDA for Parkinson’s disease (PD) and Huntington’s disease (HD) to raise awareness…Pancreatic polypeptide plasma levels in Parkinson’s disease – a marker of parasympathetic denervation
Objective: To study plasma PP concentration during sham feeding in PD patients and healthy controls, as a measure of pancreatic vagal innervation. Background: Most patients…Neurogenic Orthostatic Hypotension Burden of Illness Patient and Caregiver Survey: Impact of Symptoms
Objective: To determine the impact of neurogenic orthostatic hypotension (nOH) on the quality of life (QoL) of patients with autonomic dysfunction and the burden on…Heart rate variability in Parkinson’s Disease and idiopathic REM sleep behavior disorder and relation with other non-motor symptoms
Objective: To evaluate Heart Rate Variability (HRV) changes across sleep stages in Parkinson's Disease (PD) and idiopathic REM Sleep Behavior disorder (RBD) patients, and to…Patient-Reported Outcomes in a Prospective Real-World Study of Droxidopa for the Treatment of Neurogenic Orthostatic Hypotension
Objective: To assess the effect of droxidopa treatment on function, depression, and health-related quality of life (HRQoL) in patients with neurogenic orthostatic hypotension (nOH). Background:…Assessment of Autonomic Dysfunction in Parkinson’s Disease
Objective: Assessment of autonomic dysfunction in patients with Parkinson's disease and further comparison with patients without autonomic symptoms Background: A frequent disabling complication of Parkinson’s…
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