Body-first and brain-first PD animal models mimic human PD subtypes
Objective: Here, we aim to model body- and brain-first PD by injecting pathology in the gut and amygdala of old wild-type rats, respectively. Background: Parkinson’s…The profile of dysautonomia in the early stages of Parkinson’s disease and multiple system atrophy: the importance of using the SCOPA-AUT scale
Objective: To examine the profile of autonomic dysfunction and the utility of the SCOPA-AUT scale in distinguishing patients with early Parkinson's disease (PD) and MSA-parkinsonism (MSA-P)…Autonomic Nervous System Dysfunction in idiopathic REM sleep behaviour disorder
Objective: To characterise autonomic impairment in REM sleep behaviour disorders, and to investigate the pathophysiological link between autonomic impairment and REM sleep behaviour disorder Background:…Utilising multiple murine models to investigate sleep and circadian system dysfunction in PD
Objective: We aimed to investigate the impact of alpha-synuclein aggregation and spreading, and nigrostriatal dopaminergic degeneration on sleep homeostasis and circadian function. Background: Sleep dysfunction…Imaging progressive peripheral and central dysfunction in isolated REM sleep behaviour disorder after 3 years of follow-up
Objective: To image progression of intestinal dysfunction, cardiac sympathetic denervation, and dopaminergic nigrostriatal damage in patients with isolated REM sleep behaviour disorder (iRBD). Background: A…Factors that negatively impact the sexual function of women living with Parkinson’s disease
Objective: To investigate the impact of motor and non-motor alterations and couple adjustment on sexual function in women living with PD in Brazil. Background: Among…Prodromal non-motor symptoms in Multiple System Atrophy. Differences between cerebellar and parkinsonian phenotypes.
Objective: To determine the onset and prevalence of prodromal non-motor symptoms in patients with multiple system atrophy (MSA), both parkinsonian (MSA-P) and cerebellar (MSA-C) forms.…Gait ataxia and Autonomic dysfunction as early signs of Creutzfeldt-Jakob Disease: A Case Report
Objective: To highlight unusual early presenting symptoms of Sporadic Creutzfeldt-Jakob Disease (sCJD). Background: Prion diseases, a group of rare and fatal diseases caused by an…Relationship between cardiovascular autonomic failure and cognitive performance in the α-synucleinopathies: preliminary cross-sectional analysis of the NHSS registry
Objective: To compare cognitive performances of patients with α-synucleinopathies with or without cardiovascular dysautonomia. Background: Cardiovascular dysautonomia is a disabling non-motor feature of the α-synucleinopathies and may…Factors that negatively impact the sexual function of men living with Parkinson’s disease
Objective: To investigate the impact of motor, non-motor function, and relationship quality on sexual function in men living with PD. Background: Among the non-motor alteration…
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