Subthalamic nucleus stimulation normalises effort-based decision-making in Parkinson’s disease
Objective: To compare the influence of levodopa and subthalamic nucleus stimulation (STN-DBS) on effort-based decision-making in Parkinson’s disease (PD). Background: Idiopathic PD is a neurodegenerative…Safinamide inhibition of in vivo glutamate release in a rat model of Parkinson’s Disease
Objective: To evaluate whether safinamide inhibits in vivo glutamate (Glu) release in a rodent model of Parkinson’s disease (PD), i.e. the 6-hydroxydopamine (6-OHDA) hemilesioned rat.…Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson’s disease
Objective: To characterize the firing rate and pattern of oscillatory neurons in basal ganglia and thalamus in patients with Parkinson’s disease (PD). Background: The cardinal…Asymmetry of pallidal neuronal activity correlates with head rotation in patients with cervical dystonia
Objective: To find correlation between single unit activity in globus pallidus (GP) and neck turning in patients with cervical dystonia (CD). Background: Asymmetric GP local…Dual Competition between the Basal Ganglia and the Cortex: 1 from Action-Outcome to Stimulus-Response
Objective: We propose a model of the interaction between the cortex, the basal ganglia and the thalamus based on a dual competition during instrumental conditioning.…Motor effects induced by D1- or D2-like receptor agonists in experimental parkinsonism.
Objective: We set out to compare movement patterns induced by systemic administration of l-dopa versus D1- or D2-class DA receptor agonists in mice with unilateral…Expanding the spectrum of Faciobrachial Dystonic Seizures
Objective: A 71 years old Italian man presented progressive dysarthria and involuntary movements. Background: Within two months he developed dysarthria, progressive homolateral oromandibular and arm dystonic posture, knee…Goal-Directed Movement in Idiopathic Parkinson’s Disease and the effect of Parkin Mutations
Objective: To investigate goal-directed behavior in people with Parkinson’s disease (with and without Parkin mutations) and healthy controls using a computer based task. Background: In…Basal Ganglia Circuits for Motor and Behavioral, Emotional Performances
Objective: The present study aimed to identify which neurons in the basal ganglia (BG) target dopaminergic or GABAergic neurons in SN pars compacta (SNc) or…Quantifying postural stability differences in people with Parkinson’s disease with and without freezing of gait, using body-worn sensors
Objective: To quantify differences in postural responses to perturbations in people with Parkinson disease (PD) with and without freezing of gait (FOG+, FOG-, resp.), using…
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