Accessible Assessment of Ataxia Severity Across Diverse Populations: Integrating Large Datasets, Machine-Learning, and Online Testing
Objective: To explore whether internet-based assessments combined with machine learning approaches can support scalable characterization of ataxia severity. Background: In-person assessments of ataxia severity are…Cerebellar-cortical-spinal information flow for motor kinematic control
Objective: If M1 generates final motor outputs and cerebellar temporal kinematic information must pass through M1, then M1 should relay cerebellar frequency codes to the…Cerebellar-Basal Ganglia Circuitry in the Pathogenesis of Parkinsonian Postural Instability
Objective: To elucidate the role of impaired interactions between the basal ganglia and the cerebellum in the PI development in PD patients. Background: Postural instability…Clinical Gait Traits and Cerebellar-PPN Functional Connectivity Abnormalities in Early and Moderate-to-Advanced PD with Gait Disturbance via Perceptual Technology and MRI
Objective: To investigate clinical gait characteristics and cerebellar-pedunculopontine nucleus (PPN) functional connectivity (FC) changes in early-stage and moderate-to-advanced-stage Parkinson’s disease (PD) with gait disturbance using wearable…Frequency and Phenotypic Characterization of Genetic Causes of Sporadic Late-Onset Cerebellar Ataxia: insights from a Cohort of 315 patients
Objective: To estimate the prevalence, characterize the phenotypic spectrum, identify discriminative features of genetically determined SLOCA and implement a machine learning model for rationalizing SLOCA…Clinical Spectrum of Cerebellar Fits in Adults and Children: A Systematic Review
Objective: To systematically review the clinical characteristics, etiological associations, electroencephalographic findings, management strategies, and outcomes of cerebellar fits across pediatric and adult populations. Background: Cerebellar…Cerebellar peduncle microstructure and autonomic dysfunction in Parkinson’s disease
Objective: To investigate whether cerebellar peduncle microstructure is associated with autonomic dysfunction in Parkinson’s disease (PD). Background: Autonomic dysfunction is a common and disabling non-motor…Cerebellar connectivity predicts early response to GPi-DBS in dystonia.
Objective: To investigate the structural and functional connectivity of patients who respond early after deep brain stimulation (DBS) for dystonia. Background: DBS is an effective…Educational Innovation of Cerebellum and Ataxia Curriculum for Neurology Residents
Objective: New education method with resident as educator supervised by movement specialists to improve the knowledge and clinical skills of neurology residents in diagnosing and…Apraxia of Speech as a Presenting Feature in AP3B2 Antibody Associated Cerebellar Ataxia
Objective: We describe a unique presentation of AP3B2 antibody with apraxia of speech and cerebellar ataxia. Background: Adaptor Protein 3B2 (AP3B2) is a subunit of…
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