Re-thinking enrollment of Deep Brain Stimulation patients in Parkinson’s Disease Clinical Trials
Objective: To report on a survey of Parkinson’s disease (PD) experts on the inclusion of PD patients with deep brain stimulation (DBS) in clinical trials.…The volume of STN tissue activated by DBS and the strength of its structural connectivity with SMA predicts the effects of STN-DBS on response inhibition
Objective: To test the hypothesis that antidromic activation of the hyperdirect pathway might mediate the effects of STN-DBS on movement initiation control. Background: In PD,…Directional deep brain stimulation causes distinct intraoperative LFPs in Parkinson’s patients
Objective: To investigate the correlation between local field potential (LFP) evoked responses, recorded via the DBS lead in Parkinson’s disease patients to stimulation direction Background:…Central Pontine Myelinolysis Related Tremor Effectively Treated With Deep Brain Stimulation
Objective: To report a rare case of a patient with severe tremors related to central pontine myelinolysis (CPM), and effective treatment of this patient's tremors with…Anodic stimulation reduces corticospinal tract engagement in STN-DBS for Parkinson’s disease: a case report.
Objective: To seek how novel programming options modify the therapeutic window in a case of off-targeting DBS. Background: In Parkinson’s disease deep brain stimulation (DBS)…Combined effects of GBA mutations and STN-DBS negatively impact cognition in Parkinson’s disease
Objective: To compare the rate of change in cognition between glucocerebrosidase (GBA) mutation carriers and non-carriers with and without subthalamic nucleus deep brain stimulation (STN-DBS)…Wearable Sensor-Driven Responsive Deep Brain Stimulation for Essential Tremor
Objective: To develop and clinically validate a responsive deep brain stimulation (R-DBS) paradigm – meaning stimulation would only be delivered when needed - driven by…The Impact of DBS on Chorea- Acanthoctosis: Case Report
Objective: Chorea-acanthocytosis (ChAc) is the most common subtype of neuroacanthocytosis syndrome, characterized by the presence of misshaped spiky red blood cells (acanthocytes) and associated neurological…Cuneiform Nucleus Deep Brain Stimulation for Freezing of Gait in Parkinson’s disease. Initial clinical report.
Objective: Here we report a first in human targeting of Cuneiform Nucleus (CnF) using MR tractography, observation of intraoperative stimulation patterns and stimulation precision benefits of…Parkin Mutation and Deep Brain Stimulation
Objective: To investigate the clinical features of Parkin mutated patients who undergone subthalamic brain stimulation (DBS group) and pharmalogically treated only (Non-DBS group). Background: The…
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