Elucidating multimodal endophenotypes of APOE-ε4 in α-synucleinopathies
Objective: To systematically identify phenotypes that consistently associate with the ε4-allele of apolipoprotein E (APOE-ε4) in α-synucleinopathies. Background: The APOE-ε4 presents an elevated risk not…AMP PD: Collaborating in the discovery of biomarkers to accelerate the development of therapies for Parkinson’s disease
Objective: The Accelerating Medicines Partnership in Parkinson’s Disease (AMP PD; https://amp-pd.org) aims to identify and validate diagnostic, prognostic, and progression biomarkers for Parkinson’s Disease (PD).…Non-Tremor Motor Dysfunction is Associated with AD Biomarkers in Lewy Body Dementias
Objective: To investigate the clinical influence of Alzheimer’s disease (AD) co-pathology on motor features in Lewy Body Dementia (LBD). Background: There is considerable heterogeneity of…Analysis of the HLA locus in isolated REM sleep behavior disorder and Lewy body dementia
Objective: To examine genetic association of HLA alleles and amino acid for isolated REM sleep behavior disorder (iRBD) and Lewy body dementia (LBD). We compare…CHARACTERIZATION OF LRP10 EXPRESSION IN LEWY BODY DISORDERS AND IPSC-DERIVED BRAIN CELLS
Objective: Our objective is to characterize endogenous low-density lipoprotein-related protein 10 (LRP10) expression in human induced pluripotent stem cell (iPSC)-derived brain cell types, post-mortem brain…Differentiation of Mild Cognitive Impairment (MCI) progression to Alzheimer Disease (AD) vs Dementia with Lewy Bodies (DLB): Is this possible neuropsychologically?
Objective: Aim of the present review study was to describe and compare the neurocognitive features of MCI which could predict its progression to DLB vs…Evaluation of bedside tests of attention in delirium superimposed on Parkinson’s disease and dementia
Objective: To evaluate the ability of simple bedside tests for attention to detect delirium in those with and without underlying neurodegenerative diseases, including Parkinson’s disease…Early-onset Dementia with Lewy Bodies and Parkinson’s Disease Dementia: A Population-based Study (2010-2015).
Objective: To examine the incidence, clinical features, and survival of early-onset Dementia with Lewy Bodies and Parkinson’s Disease Dementia (DLB/PDD) (≤55 years of age) in…Utilizing digital biomarkers to explore risk factors for falls in patients with Lewy Body Dementia
Objective: To analyze risk factors for falls in individuals with Lewy Body Dementia (LBD) enrolled in PRESENCE. Background: PRESENCE was a phase 2 clinical trial…Differential methylation signatures in Lewy body dementia
Objective: This study aimed to compare the DNA methylome of Lewy body dementia (LBD) patients and healthy controls. Background: LBD is the second most common…
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