Synaptic function in Parkinson’s disease associated with GBA mutations
Objective: To investigate the pathological substrate of impaired cognition in Parkinson’s disease (PD) associated with glucocerebrosidase (GBA) mutation. Background: Mutations in glucocerebrosidase gene (GBA), originally…Prodromal symptoms in clinically diagnosed dementia with Lewy bodies stratified by Lewy body pathology on autopsy
Objective: Compare prodromal neuropsychiatric, sleep, and motor symptoms in patients clinically diagnosed with dementia with Lewy bodies (DLB) with and without Lewy body pathology on…Cortical FDG-PET patterns predict long-term motor progression and disability milestones in Parkinson’s disease
Objective: To evaluate the accuracy of single-subject FDG-PET in predicting motor and cognitive long-term progression in Parkinson's disease Background: The progression of Parkinson's disease is…Functional connectivity and microstructural alterations in regions of synaptic density loss in DLB and PDD
Objective: We aimed to investigate whether functional connectivity and white matter integrity is altered in regions exhibiting reduced synaptic density, as measured by [11C]UCB-J-PET,in Dementia with…A Lewy body disease of widely confirmed Lewy bodies in the cerebral cortexes including the occipital lobe without pathological changes in the hippocampal CA2/3 region
Objective: We present Lewy body disease (LBD) showing unique neuropathological findings which are widely recognized Lewy bodies (LBs) in the cerebral cortexes including the occipital…Visual hallucinations in Lewy Body Disease are characterised by impaired sensory integration
Objective: To test whether increased reliance on prior knowledge is associated with visual hallucinations in Lewy Body Disease (LBD: Parkinson’s disease and Dementia with Lewy…Increased lysosphingolipids levels in blood of patients with multiple system atrophy
Objective: To estimate activity of lysosomal enzymes and lysosphingolipids concentration in dry blood spot of patients with synuleinopathies: Parkinson’s disease (PD), dementia with Lewy bodies…Patterns of Lewy body dementia diagnosis and treatment in Florida
Objective: To characterize the demographic and treatment characteristics for the Lewy body dementia (LBD) population in Florida using a statewide clinical data research network. Background:…The frequency and impact of mutations in the GBA gene and APOε4 polymorphisms on the clinical features of Dementia with Lewy Bodies among Ashkenazi Jews
Objective: We aimed to explore the frequency and clinical impact of GBA mutations and APOε4 polymorphisms in a cohort of Ashkenazi Jewish (AJ) patients with…Extrastriatal dopaminergic and serotonergic pathways in Parkinson’s disease and in dementia with Lewy bodies: a 123I-FP-CIT study
Objective: To evaluate the common and divergent dopaminergic and serotonergic impairment in Parkinson's disease and dementia with Lewy bodies using 123I-FP-CIT imaging. Background: Striatal dopaminergic…
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