Atypical parkinsonism and psychiatric disorder in hereditary diffuse leukoencephalopathy with spheroids: a novel variant in the CSF1R gene
Objective: We describe the clinical, radiological and neuropathological phenotype of a patient carrying a novel variant in the CSF1R gene. Background: Hereditary diffuse leukoencephalopathy with…Exploring brain mechanisms of identity attribution in presence hallucinations of Parkinsonian origin
Objective: Study cognitive, behavioral correlates of identity of presence hallucinations in Parkinson’s disease. Background: Presence hallucination (PH), the sensation that someone is nearby when no…Long-term dementia prevalence in Parkinson disease: Glass half-full?
Objective: To determine long-term, cumulative dementia prevalence rates in Parkinson disease (PD) using data from two large, ongoing, prospective observational studies. Background: Dementia is reported to occur in…Mitochondrial DNA copy number is associated with the severity of motor symptoms and dementia in Parkinson’s disease
Objective: We aimed to investigate the diagnostic and prognostic role of blood mitochondrial DNA copy number (mtDNA-CN) measured by whole genome sequencing (WGS) in relation…Oculomotor parameters measured during free viewing of video differentiate Parkinson’s disease from progressive supranuclear palsy
Objective: Characterize oculomotor phenotypes comprised of saccade, pupil, and blink behaviour for progressive supranuclear palsy (PSP) and Parkinson’s disease (PD) with differing degrees of cognitive…Is an integrated Parkinson’s Dementia Service the way forward?
Objective: To illustrate the role of a single team in managing all facets of Parkinson’s Background: The Cardiff and Vale Parkinson’s service is an integrated,…Predictors of cognitive deficits in patients with idiopathic normal pressure hydrocephalus – a pilot MRI volumetric study
Objective: The pilot study aimed to identify neuroanatomical predictors of cognitive performance in patients with iNPH. Background: Idiopathic normal pressure hydrocephalus (iNPH) is a specific…Unusual Neuronal Intranuclear Inclusion Disease (NIID) with initial presentation mimicking recurrent Transient Global Amnesia (TGA)
Objective: Our aim is to report an unusual Neuronal intranuclear inclusion disease (NIID) case of a woman who initially presented recurrent Transient Global Amnesia (TGA)…Safety profile of pimavanserin therapy in elderly patients with neurodegenerative disease-related neuropsychiatric symptoms: a Phase 3b study
Objective: To evaluate the safety profile of pimavanserin in patients with neuropsychiatric symptoms related to neurodegenerative disease (NDD). Background: Patients with NDD including Parkinson’s disease…Evaluation of a novel Phosphodiesterase 5 inhibitor as a potential therapeutic agent in P301S transgenic mouse model of tauopathy.
Objective: In the current study, we evaluated a newly developed compound with a 1,3,5-trisubstituted pyrazoline scaffold with an improved PDE5 inhibitory potency as a potential…
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