Regulation of aberrant striatal oscillations by glutamate receptor blockade in parkinsonian non-human primates
Objective: To study the abnormal striatal oscillations and regulation of striatal oscillatory activities by micro-infusion of glutamate receptor antagonist in the non-human primate model of…Distinct pattern of striatal dopaminergic depletion in patients with parkin mutation
Objective: As a pilot study, this study was aimed to perform the detailed analysis of the striatal DAT density in patients with early-onset Parkinson's disease…Exploratory Clinical study of role of cerebral dopamine neurotrophic factor (CDNF) mediating endoplasmic reticulum stress (ERS) in Parkinson Disease
Objective: 1: to identify and measure endogenous CDNF levels in peripheral whole blood of healthy control subjects and to examine CNDF expression development profile across the life…Serotonergic, Dopaminergic Disruptions and Related Non-Motor Features Throughout the Course of Parkinson’s Disease: A Transversal PET Study
Objective: To explore the progression of DA and 5-HT lesions during the course of Parkinson’s disease (PD) and their respective contribution to the pathogenesis of…Parkinson’s disease disrupts motor skill learning that requires improvement of a speed-accuracy trade-off
Objective: 1) To test whether PD reduces the ability to improve motor acuity (speed-accuracy trade-off performance) in goal-directed movements; 2) To examine the effect of…Dopamine depletion impairs gait automaticity by altering cortico-striatal and cerebellar processing in Parkinson’s disease
Objective: Investigating the role of dopaminergic medication on the neural mechanisms underlying lower limb motor automaticity during fMRI in 23 patients with PD that were…Catecholamines’ concentration ratio in plasma of early diagnosed treatment-naive patients with Parkinson disease
Objective: To investigate the concentration of some catecholamines (dopamine, DOPA and DOPAC) in the blood plasma and their ratio to each other depending on sex, form and…Dopamine Normalizes Putamen to Insula Activation Shift During Choice Reaction Time Task in PD
Objective: We investigated Parkinson’s disease (PD) patients during a functional MRI Choice Reaction Time (CRT) task and determined whether brain activations are altered by dopamine. Background:…Alpha-synucleinopathy and mitochondrial dysfunction in a cell based model of neurodegeneration: Implications in the pathogenesis of sporadic Parkinson’s disease
Objective: To elucidate the role of α-synuclein, parkin and mitochondria in a cell-based model of neurodegeneration relevant to Parkinson's disease pathogenesis. Background: The suggested mechanisms…Functional MAOB gene intron 13 polymorphism predicts putaminal dopamine turnover in de novo Parkinson’s disease
Objective: To examine the effects of common functional polymorphisms in genes involved in dopamine metabolism on striatal dopamine turnover estimated as the inverse of the…
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