DAT-IQ improves power to detect longitudinal change in DaT deficit in SURE-PD3
Objective: DATIQ has been developed as a novel analytical approach to improve the sensitivity and statistical efficiency of dopamine transporter (DaT) SPECT quantification over previously…Is dopamine replacement therapy an addictive drug?
Objective: To identify common clinical and imaging abnormalities in Parkinson's disease patients and heroin-dependent patients compared with healthy controls in order to better understand the pathophysiology…Behavioral effects of stimulated dopamine release and D2-like receptor displacement in Parkinson’s patients with impulse control disorder
Objective: To evaluate behavioral effects of stimulated dopamine (DA) release in Parkinson’s disease (PD) by assessing D2/3 receptor (DA-R) displacement on PET imaging Background: Previous…Do Parkinson’s disease medications have an effect on gut microbiome? A case-control study
Objective: To investigate the difference in the gut microbiota between drug-naïve and medicated PD patients and focus on the association between gut microbiota and anti-PD medications. Background:…Parkinson’s disease patients with hallucinations exhibit dopaminergic degeneration and cortical thinning
Objective: Examine whether Parkinson’s disease patients (PD) who experience hallucinations (PD+hall) exhibit a greater decline in striatal dopamine and corresponding posterior cortical decline relative to…Multimodal, longitudinal investigation in Dopa-responsive dystonia
Objective: To perform a detailed longitudinal clinical and neurophysiological investigation in monogenic Dopa-responsive dystonia (DRD) patients with mutations in the guanosine triphosphate cyclohydrolase 1 (GCH1)…Is Generalized and Segmental Dystonia Accompanied by Impairments of the Dopaminergic System?
Objective: To investigate functional dopaminergic impairments in dystonia, we compared patients with dystonia and Parkinson’s disease (PD) with normal controls using neuromelanin-sensitive magnetic resonance imaging…Connectomic Analysis of SNc and VTA Projections to the Striatum and Cortex
Objective: To investigate the dopaminergic neural tracts of healthy individuals using Diffusion MRI on Human Connectome Project Data. Background: Classically, the DA system has been…The effects of acute administration of VMAT2 inhibitors on extracellular levels of dopamine, norepinephrine, 5-HT and histamine in the striatum and medial prefrontal cortex
Objective: To evaluate the effects of reversible VMAT2 inhibitors (deutetrabenazine, tetrabenazine and valbenazine) on extracellular levels of monoamines and their acidic metabolites in rat striatum…Istradefylline/L-DOPA combination therapy for Parkinson’s disease and blood markers of glycolytic energy homeostasis
Objective: To clarify the potential to preserve glycolytic energy homeostasis (GEH) with the Istradefylline combined to L-DOPA (IST-LD), and to prevent LD-induced weight loss and…
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