Generation of dopaminergic neurons for studying Parkinson’s disease using patient blood cells
Objective: To study the molecular mechanism of G2385R mutation of LRRK2 gene in PD developing, dopaminergic neurons are derived from patient specific induced pluripotent stem…Amelioration of αLPHA-synuclein aggregation and motor behavior deficits by apocyanin in intranigral lipopolysaccharide induced animal model of Parkinson’s disease
Objective: The present study evaluated the therapeutic potentials of apocyanin for the treatment of neurobehavioral consequences in LPS induced PD model. Background: Parkinson's disease (PD),…Modulating neuronal activity in dopaminergic neurons to promote their survival
Objective: To manipulate the activity of dopaminergic (DA) neurons in culture using pharmacological and molecular tools to promote their survival. Background: Parkinson's disease is a…A computational model of iron transport between the blood circulation and the brain
Objective: To create a mechanistic computational model of iron transport between the circulation and brain, permitting in silico investigation of homeostatic regulation of iron at…A novel C. elegans model for identification of small molecules that target alpha-synuclein-mediated toxicity
Objective: To develop a novel transgenic C. elegans model to study dopaminergic neurodegeneration mediated by alpha-synuclein. Background: Targeting alpha-synuclein could be a disease-modifying strategy for…Exploring therapeutic viability of a non-dopaminergic target for Parkinson’s disease
Objective: Non-dopaminergic protein drug targets are of high interest to develop adjuvant treatments for currently insufficiently addressed symptoms of PD. RGS4, a regulator of G-protein…Modulation of microglia function in the prion-like spreading of α-synuclein in the murine brain
Objective: We aimed to analyze the influence of two microglia-related pathways on the accumulation of α-synuclein aggregates and neurodegeneration after intracerebral injection of sonicated murine…Piper longum L. alkaloids inhibit lipopolysaccharide-stimulated microglial activation and protect nigral dopaminergic neurons
Objective: The ethanol-extracted alkaloids from the dry seeds of Piper longum L. (PLL) (family Piperaceae) PLA contain numerous compounds. We evaluate the potential of PLA…Sodium butyrate attenuates rotenone-induced neurodegeneration via enhancing autophagy and preventing α-synuclein aggregation
Objective: To investigate whether sodium butyrate (NaB) could enhance autophagy and thus exert a neuroprotective effect through the modulation of α-synuclein in animal models of…Generation and characterization of midbrain organoids from iPSCs of familial Parkinson’s disease
Objective: To generate and characterize human pluripotent stem cell (iPSCs) - derived midbrain cerebral organoids of patients with Parkinson's disease. Background: Parkinson's disease is a…
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