Dopamine Receptor Gene Polymorphism in L-Dopa Induced Dyskinesia- A Study from Eastern India
Objective: We intended to find the frequency of Single Nucleotide Polymorphism (SNP) rs6280 in DRD3 gene in PD patients with and without Levodopa Induced Dyskinesia…Subanesthetic infusion of ketamine produces long-term reduction in levodopa-induced dyskinesia and depression in individuals with Parkinson’s Disease
Objective: An open-label, dose-finding Phase I/II clinical trial was conducted to test safety and tolerability of low-dose ketamine infusion to treat levodopa-induced dyskinesia (LID), and…Determination of metabotropic glutamate 2 receptor distribution with [3H]-LY-341,495 in hemi-parkinsonian rats with L-DOPA-induced dyskinesia
Objective: To determine the distribution and density of metabotropic glutamate 2 (mGlu2) receptors in the motor loop of the basal ganglia in 6-hydroxydopamine (6-OHDA)-lesioned rats…Impact of culture on Impulse control disorders and correlation with levodopa-induced dyskinesia in Parkinson’s disease in Egypt .
Objective: to study the impact of culture on the categories of impulse control disorders ( ICD ) in PD and its association with levodopa-induced dyskinesia…The study of genetic factors in levodopa-induced motor complications development in Russian patients with Parkinson’s disease
Objective: This study is aimed to explore the relationship between the single nucleotide polymorphisms (SNPs) in dopamine and serotonin metabolism genes, other neurotransmitter systems genes…Axon terminal hypertrophy of striatal projection neurons with levodopa-induced dyskinesia priming
Objective: We examined whether levodopa-induced dyskinesia (LID) and axon terminal hypertrophy gradually develop with repeated levodopa treatment in Parkinsonian rats to prove that the hypertrophy…Motor function in Parkinson´s disease during 16h treatment with intravenously (DIZ101), subcutaneously (DIZ102), or intestinally (LCIG) infused levodopa
Objective: To compare the effect of intravenous (DIZ101) and subcutaneous (DIZ102) continuous 16h infusion of a continuously buffered acidic levodopa/carbidopa solution with levodopa/carbidopa intestinal gel…Dyskinesia profiles after dose challenges with L-dopa vs L-dopa plus ropinirole: a pilot study
Objective: To investigate possible differences in the profiles of abnormal involuntary movements (AIMs) in patients with Parkinson’s disease (PD) after dose challenge with L-dopa alone…Amelioration of Levodopa-induced Dyskinesias using Genetic Silencing of Striatal CaV1.3 in Parkinsonian Rats: Impact of Sex and Advancing Age
Objective: To advance understanding of striatal CaV1.3 (cacna1d) channel silencing as a therapeutic approach to reduce levodopa-induced dyskinesias (LID), a side effect of long-term escalating…Effect of the mGlu2/3 orthosteric agonist LY-404,039 on dyskinesia, psychosis-like behaviours, and parkinsonism in the MPTP-lesioned marmoset
Objective: To assess the effect of LY-404,039 on dyskinesia, psychosis-like behaviours (PLBs) and parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset model of Parkinson’s disease (PD). Background:…
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