Natural progression of patients with Parkinson disease on less pulsatile levodopa therapy
Objective: To evaluate the natural progression of Parkinson disease (PD) in patients on less pulsatile levodopa therapy (LPT). Background: Previously we have shown that patients…Levodopa-induced unilateral orofacial dystonia in multiple system atrophy : case report and video presentation
Objective: The study reports a case of lateral orofacial dystonia in a multiple system atrophy (MSA) patient treated with levodopa, and discusses the clinical characteristics…Proof-of-concept study testing bevantolol (SOM3355) as treatment of chorea in Huntington’s disease
Objective: Proof-of-concept phase IIa study assessing bevantolol (SOM3355) efficacy and safety in reducing chorea in Huntington’s disease (HD). Background: Bevantolol hydrochloride, a β1‐adrenoceptor antagonist used…Analysis of Amantadine formulations for OFF and Dyskinesia in Parkinson Disease
Objective: Evaluate the effects of amantadine formulations on the treatment of OFF and dyskinesia in Parkinson’s patients. Background: There are currently three formulations of amantadine…Dyskinesia, Pain, and Quality of Life in Parkinson’s Disease: Post Hoc Analysis From the DYSCOVER Study
Objective: Evaluate correlations between dyskinesia, health-related quality of life (HRQoL), activities of daily living (ADL), and pain in patients with advanced Parkinson’s disease (PD) who…Distinct patterns of dyskinetic and dystonic features following D1 or D2 receptor stimulation in a mouse model of parkinsonism
Objective: We set out to compare patterns of dyskinetic behaviours induced by the systemic administration of L-DOPA and D1 or D2 receptor (D1R, D2R) agonists…Wearable sensor motor outcomes across patients with Parkinson’s disease from Asian, Black, and Caucasian ethnicity in the United Kingdom
Objective: To determine the effect of ethnic background on motor scores in people with Parkinson’s disease (PwP) using objective measurement. Background: Limited evidence has suggested…The influence of culture on the relationship between subjective and objective assessments of dyskinesia severity.
Objective: To explore the relationship and rate of agreement between patient and clinician evaluation of dyskinesia severity and impact on function across multiple cultures. Background:…A Case of Autoimmune Orofacial Dyskinesia associated with Striational Antibody
Objective: This is a case of steroid-responsive, autoimmune orofacial dyskinesia associated with extremely elevated striational [striated muscle] antibody. We present this instructive case to add…Local Field Potentials (LFP) used to guide treatment of biphasic dyskinesias in a patient with Parkinson’s Disease (PD)
Objective: To identify, characterize and treat dyskinesias and off time in a patient with PD via the use of gamma and beta peak LFP using…
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